Membrane association of FtsY, the E-coli SRP receptor
Membrane association of FtsY, the E-coli SRP receptor
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DOI：
10.1016/s0014-5793(97)01238-6
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发表时间：
1997-10-27
期刊：
影响因子：
3.5
通讯作者：
Luirink, J
中科院分区：
文献类型：
--
作者：
deLeeuw, E;Poland, D;Luirink, J
FtsY是真核生物SRP受体（SR α）的大肠杆菌同源物，位于大肠杆菌的细胞质和内膜中。与SR α类似，FtsY由两个主要结构域组成：强酸性N-末端结构域（A）和C-末端GTP结合结构域（NG），其晶体结构最近已被确定。在体内和体外表达的结构域，以检查它们的亚细胞定位，结果表明，这两个结构域与膜，但协会的性质不同。(C)1997年欧洲生物化学学会联合会。
FtsY, the Escherichia coli homologue of the eukaryotic SRP receptor (SR alpha), is located both in the cytoplasm and in the inner membrane of E. coli, Similar to SR alpha, FtsY consists of two major domains: a strongly acidic N-terminal domain (A) and a C-terminal GTP binding domain (NG) of which the crystal structure has recently been determined. The domains were expressed both in vivo and in vitro to examine their subcellular localization, The results suggest that both domains associate with the membrane but that the nature of the association differs. (C) 1997 Federation of European Biochemical Societies.