Prostaglandins, leukotrienes, and other arachidonic acid metabolites in the pathogenesis of otitis media
Prostaglandins, leukotrienes, and other arachidonic acid metabolites in the pathogenesis of otitis media
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前列腺素、白三烯和其他花生四烯酸代谢物在中耳炎发病机制中的作用
DOI：
10.1288/00005537-198809000-00013
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
T. Jung
中科院分区：
文献类型：
--
作者：
T. Jung
在中耳炎的多种炎症介质中，花生四烯酸（AA）的代谢产物如花生四烯酸（PGs）和白三烯（LTs）在中耳炎的发病机制中起重要作用。为了研究AA代谢物在中耳炎发病机制中的作用，测定了人和平行动物中耳炎模型中耳积液（中耳积液）中AA代谢物的浓度，并研究了AA代谢抑制剂、抗生素和鼓膜造孔管（TT）对OM动物模型结局的影响。
Among the various inflammatory mediators of otitis media (OM), metabolites of arachidonic acid (AA) such as prostaglandins (PGs) and leukotrienes (LTs) appear to play an important role in the pathogenesis of otitis media. In an effort to investigate the role of AA metabolites on the pathogenesis of otitis media, concentrations of AA metabolites were measured in middle ear effusion (MEE) from human and paralleling animal models of otitis media and the effects of inhibitors of AA metabolism, antibiotics, and tympanostomy tube (TT) on the outcome of animal models of OM were studied.