Short-term respiratory effects of e-cigarettes in healthy individuals and smokers with asthma
Short-term respiratory effects of e-cigarettes in healthy individuals and smokers with asthma
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DOI：
10.1111/resp.13180
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发表时间：
2018-03-01
期刊：
影响因子：
6.9
通讯作者：
Behrakis, Panagiotis K.
中科院分区：
文献类型：
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作者：
Lappas, Andreas S.;Tzortzi, Anna S.;Behrakis, Panagiotis K.
背景与目的本研究探讨了电子烟（ECS）直接呼吸效应的持续时间，并验证了电子烟对哮喘患者的直接呼吸效应比健康吸烟者（HS）更显著的假设。方法54例吸烟者（健康组27例）和间歇性哮喘（轻度哮喘（MA）组27例）采用标准雾化设置进行对照（不含液体，电子烟筒内不含电阻线圈）和ECS实验。脉冲振荡阻抗(Z)、电阻(R)、电抗(X)和呼出一氧化氮分数（FeNO）分别在控制和实验前、0、15和30min测量。结果对照组无明显变化。在实验阶段，ecs后立即，两组在5Hz （Z5）时均表现出呼吸系统总阻抗显著增加(P
Background and objectiveThis study investigated the duration of immediate respiratory effects of e-cigarette smoking (ECS) and tested the hypothesis that ECS has more prominent effects in asthmatics compared with healthy smokers (HS).MethodsFifty-four smokers, 27 healthy (HS group) and 27 with intermittent asthma (mild asthma (MA) group) underwent a control session (no liquid, no resistor coil inside e-cigarette cartridge) and an experimental session of ECS using standardized puffing settings. Impulse oscillometry impedance (Z), resistance (R), reactance (X) and fractional exhaled nitric oxide (FeNO) were measured before and 0, 15 and 30min after control and experimental sessions.ResultsControl session revealed no significant changes. In the experimental session, immediately post-ECS, both groups exhibited a significant increase in respiratory system total impedance at 5Hz (Z5) (P