Selective synthesis of (Z)-2-enynyl-2-hydroxy-imidazolidine-4,5-diones via Cu(I)-mediated multicomponent coupling of terminal alkynes, carbodiimides and oxalyl chloride.
Selective synthesis of (Z)-2-enynyl-2-hydroxy-imidazolidine-4,5-diones via Cu(I)-mediated multicomponent coupling of terminal alkynes, carbodiimides and oxalyl chloride.
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DOI：
10.1039/c4ob00185k
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发表时间：
2014-05
影响因子：
3.2
通讯作者：
F. Zhao;Yuexing Li;Yang Wang;Wen‐Xiong Zhang;Z. Xi
中科院分区：
文献类型：
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作者：
F. Zhao;Yuexing Li;Yang Wang;Wen‐Xiong Zhang;Z. Xi
(Z)-2-烯炔基-2-羟基-咪唑烷-4,5-二酮 2 是首次通过 Cu(I) 介导的末端炔烃、碳二亚胺和草酰氯两分子之间的 (Z) 选择性孪生偶联合成。对2a进行进一步转化，得到高度官能化的螺杂环化合物5。
(Z)-2-Enynyl-2-hydroxy-imidazolidine-4,5-diones 2 are synthesized for the first time via Cu(I)-mediated (Z)-selective geminal coupling among two molecules of terminal alkynes, carbodiimides, and oxalyl chloride. Further transformation of 2a is performed to yield a highly functionalized spiro heterocyclic compound 5.