Vagus nerve stimulation in 436 consecutive patients with treatment-resistant epilepsy: Long-term outcomes and predictors of response
Vagus nerve stimulation in 436 consecutive patients with treatment-resistant epilepsy: Long-term outcomes and predictors of response
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DOI：
10.1016/j.yebeh.2010.10.017
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发表时间：
2011-01-01
影响因子：
2.6
通讯作者：
Doyle, Werner K.
中科院分区：
文献类型：
--
作者：
Elliott, Robert E.;Morsi, Amr;Doyle, Werner K.
目的：本研究的目的是评估迷走神经刺激在连续系列成人和儿童难治性癫痫（TRE）患者中的疗效和安全性。在对1997年11月至2008年4月期间接受迷走神经刺激器植入治疗IRE的436例连续患者前瞻性创建的数据库进行回顾性审查时，植入时，220例（50.5%）女性和216例（49.5%）男性的年龄范围为1 - 76岁（平均值：29.0 +/- 16.5）。初次植入组中有33名患者（7.6%）随访不充分（162名患者（40.5%）癫痫控制≥ 75%，255名患者（63.75%）改善≥ 50%，
Objective: The goal of this study was to assess the efficacy and safety of vagus nerve stimulation in a consecutive series of adults and children with treatment-resistant epilepsy (TRE).Methods: In this retrospective review of a prospectively created database of 436 consecutive patients who underwent vagus nerve stimulator implantation for IRE between November 1997 and April 2008, there were 220 (50.5%) females and 216 (49.5%) males ranging in age from 1 to 76 years at the time of implantation (mean: 29.0 +/- 16.5). Thirty-three patients (7.6%) in the primary implantation group had inadequate follow-up (= 75% seizure control in 162 patients (40.5%), >= 50% improvement in 255 patients (63.75%), and