Manual therapy as an effective treatment for fibrosis in a rat model of upper extremity overuse injury.
Manual therapy as an effective treatment for fibrosis in a rat model of upper extremity overuse injury.
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DOI：
10.1016/j.jns.2015.12.029
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发表时间：
2016-02-15
影响因子：
4.4
通讯作者：
Barbe MF
中科院分区：
文献类型：
--
作者：
Bove GM;Harris MY;Zhao H;Barbe MF
腕管综合征和其他类型的手和手腕累积性创伤障碍的主要临床特征包括疼痛和功能障碍。机制细节仍在调查中，但可能涉及组织炎症和/或纤维化。我们检测了模拟手法疗法(MMT)作为治疗大鼠感觉运动行为下降和前臂组织纤维化过程增加的有效性，这些大鼠在12周的高重复高力(HRHF)到达和抓握任务中发生。研究对象为青年雌性大鼠：食物限制对照组(FRC，n=12)、训练6周后进行HRHF任务12周的大鼠(HRHF-CON，n=11)和接受模型手动治疗(HRHF-MMT，n=5)的HRHF任务大鼠，为期12周。接受MMT的大鼠表现出较少的不适相关行为，并且在HRHF任务中表现得越来越好。握力虽然在训练后有所下降，但在MMT后有所改善。12周龄HRHF-CON大鼠的纤维神经和结缔组织改变(胶原和转化生长因子-β-1沉积增加)在12周HRHF-MMT大鼠中显著减少。这些观察结果支持将手法疗法作为一种预防重复性运动障碍的研究。
Key clinical features of carpal tunnel syndrome and other types of cumulative trauma disorders of the hand and wrist include pain and functional disabilities. Mechanistic details remain under investigation but may involve tissue inflammation and/or fibrosis. We examined the effectiveness of modeled manual therapy (MMT) as a treatment for sensorimotor behavior declines and increased fibrogenic processes occurring in forearm tissues of rats performing an high repetition high force (HRHF) reaching and grasping task for 12 weeks. Young adult, female rats were examined: food restricted control rats (FRC, n=12); rats that were trained for 6 weeks before performing the HRHF task for 12 weeks with no treatment (HRHF-CON, n=11); and HRHF task rats received modeled manual therapy (HRHF-MMT, n=5) for 5 days/week for the duration of the 12-week of task. Rats receiving the MMT expressed fewer discomfort-related behaviors, and performed progressively better in the HRHF task. Grip strength, while decreased after training, improved following MMT. Fibrotic nerve and connective tissue changes (increased collagen and TGF-β1 deposition) present in 12-week HRHF-CON rats were significantly decreased in 12-week HRHF-MMT rats. These observations support the investigation of manual therapy as a preventative for repetitive motion disorders.