Whole-body biodistribution and radiation dosimetry of the new cardiac tracer 99mTc-N-DBODC
Whole-body biodistribution and radiation dosimetry of the new cardiac tracer 99mTc-N-DBODC
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DOI：
10.2967/jnumed.108.053132
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发表时间：
2008-08-01
影响因子：
9.3
通讯作者：
Duatti, Adriano
中科院分区：
文献类型：
--
作者：
Cittanti, Corrado;Uccelli, Licia;Duatti, Adriano
我们的目的是评价新型心肌灌注示踪剂双[（二甲氧基丙基膦基）乙基]乙氧基乙胺N，N '-双（乙氧基乙基）二硫代氨基甲酸酯氮锝（V）（Tc-99 m-N-DBODC）在健康人体志愿者中的安全性和生物分布行为。方法：10名健康男性志愿者在应激和静息状态下注射99 mTc-N-DBODC。在注射后5、30、60、240和1，440分钟收集前部和后部平面γ照相机图像，通过感兴趣区域分析定量器官摄取。通过在不同时间点收集血液和尿液样品来确定体液中的示踪剂动力学。结果：（TcN）-Tc-99 m-DBODC注射后在心肌内有明显蓄积，并有较长的滞留时间。在静息条件下，注射后5分钟，心脏、肺和肝脏的摄取分别为给药活性的1.67% +/-0.13%、1.16% +/-0.07%和10.85% +/-1.72%。在应激条件下，心脏摄取显著更高（2.07% +/- 0.22%）。注射后60和240 min，肝脏中的放射性分别降至3.64% +/- 0.98%和2.37% +/- 0.48%。这种快速的肝脏清除率导致有利的心脏-肝脏比，在示踪剂给药后60分钟，静息时达到0.74 +/- 0.13，运动时达到1.26 +/- 0.28。辐射剂量估计值与其他心肌灌注阳离子化合物获得的结果相当。结论：Tc-99 m-N-DBODC在心肌中的高摄取和快速肝脏洗脱将允许早期获得左心室的SPECT图像并具有优异的质量。
Our purpose was to evaluate the safety profile and biodistribution behavior in healthy human volunteers of the new myocardial perfusion tracer bis[(dimethoxypropylphosphanyl)ethyl]ethoxyethylamine N,N'-bis(ethoxyethyl)dithiocarbamato nitrido technetium (V) (Tc-99m-N-DBODC). Methods: Ten healthy male volunteers were injected with 99mTc-N-DBODC under both stress and rest conditions. Anterior and posterior planar gamma-camera images were collected at 5, 30, 60, 240, and 1,440 min after injection, with organ uptake quantified by region-of-interest analysis. Tracer kinetics in body fluids were determined by collecting blood and urine samples at different time points. Results: After injection, (TcN)-Tc-99m-DBODC showed significant accumulation in the myocardium and prolonged retention. Under rest conditions, uptake in the heart, lungs, and liver at 5 min after injection was 1.67% +/- 0.13%, 1.16% +/- 0.07%, and 10.85% +/- 1.72%, respectively, of administered activity. Under stress conditions, heart uptake was significantly higher (2.07% +/- 0.22%). Radioactivity in the liver decreased to 3.64% +/- 0.98% and 2.37% +/- 0.48% at 60 and 240 min, respectively, after injection. This rapid liver clearance led to favorable heart-to-liver ratios, reaching values of 0.74 +/- 0.13 at rest and 1.26 +/- 0.28 during exercise 60 min after tracer administration. Radiation dose estimates were comparable to those obtained with other myocardial perfusion cationic compounds. Conclusion: The high uptake in the myocardium and the fast liver washout of Tc-99m-N-DBODC will allow SPECT images of the left ventricle to be acquired early and with excellent quality.