Exercise Enhances Hippocampal-Dependent Learning in the Rat: Evidence for a BDNF-Related Mechanism
Exercise Enhances Hippocampal-Dependent Learning in the Rat: Evidence for a BDNF-Related Mechanism
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DOI：
10.1002/hipo.20631
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发表时间：
2009-01-01
期刊：
影响因子：
3.5
通讯作者：
Kelly, Aine M.
中科院分区：
文献类型：
--
作者：
Griffin, Eadaoin W.;Bechara, Ranya G.;Kelly, Aine M.
据报道，短时间的强迫运动可能通过脑源性神经营养因子（BDNF）介导的机制，选择性地诱导大脑依赖性认知功能的增强。在这项研究中，我们报告说，1周的跑步机运行显着提高了物体位移（空间）和物体替代（非空间）的学习。这些行为改变伴随着齿状回、海马和嗅周皮质中BDNF蛋白表达的增加。通过侧脑室注射BDNF蛋白来模拟运动对物体替代的影响。这些数据与运动有可能增强年轻健康大鼠认知功能的假设一致，可能是通过增加特定脑区BDNF表达的机制。(C)2009 Wiley-Liss，Inc.
Short periods of forced exercise have been reported to selectively induce enhancements in hippocampal-dependent cognitive function, possibly via brain-derived neurotrophic factor (BDNF)-mediated mechanisms. In this study, we report that 1 week of treadmill running significantly enhanced both object displacement (spatial) and object substitution (nonspatial) learning. These behavioral changes were accompanied by increased expression of BDNF protein in the dentate gyrus, hippocampus, and perirhinal cortex. The effects of exercise on object substitution were mimicked by intracerebroventricular injection of BDNF protein. These data are consistent with the hypothesis that exercise has the potential to enhance cognitive function in young healthy rats, possibly via a mechanism involving increased BDNF expression in specific brain regions. (C) 2009 Wiley-Liss, Inc.