Type 2 diabetes from pediatric to geriatric age: analysis of gender and obesity among 120 183 patients from the German/Austrian DPV database
Type 2 diabetes from pediatric to geriatric age: analysis of gender and obesity among 120 183 patients from the German/Austrian DPV database
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DOI：
10.1530/eje-12-0143
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发表时间：
2012-08-01
影响因子：
5.8
通讯作者：
Holl, R. W.
中科院分区：
文献类型：
--
作者：
Awa, Wendy L.;Fach, E.;Holl, R. W.
目的：分析2型糖尿病(T2 DM)的临床表型与年龄、性别和体重指数的关系。方法：对德国/奥地利多中心糖尿病患者数据库中的120 183例T2 DM患者的匿名资料按年龄或确诊年龄(0~19岁、20~39岁、40~59岁、60~79岁、<80岁)进行分析。结果：男性占51.3%，平均年龄67.1±12.7岁，平均病程9.9±9.1年。在青春期(20-60岁)被确诊的女孩比男孩多，成年(20-60岁)男性比女性多。当确诊年龄为60岁时，性别差异不存在。患者平均肥胖(BMI：30.5±6.1 kg/m(2))，BMI值显著高于德国人群。BMI差距在较年轻的年龄组中最大，并随着年龄的增长而缩小。成年女性明显比男性肥胖。与非肥胖者相比，肥胖者更常有糖化血红蛋白升高(=7.5%)、高血压或血脂异常(不分年龄)、微量白蛋白尿(成年人)或视网膜病变(老年人)。高血压、血脂异常或微量白蛋白尿的男性多于女性(20~60岁)，而女性高血压或血脂异常的女性(<60岁)多于男性。结论：青春期女性T2 DM患者多于男性，而成年后以男性为主。男性T2 DM患者的BMI相对较低，确诊时年龄较小的患者肥胖程度较高。年龄、性别和BMI也与代谢控制不良和心血管疾病的合并症/并发症有关。
Aim: To characterize the clinical phenotype of type 2 diabetes mellitus (T2DM) with respect to age, gender, and BMI.Method: Anonymized data of 120 183 people with T2DM from the German/Austrian multicenter Diabetes Patienten Verlaufsdokumentation database were analyzed based on chronological age or age at diagnosis (0-19, 20-39, 40-59, 60-79, and >= 80 years). Age, gender, and BMI comparisons with clinical phenotype were made using chi(2) and Kruskal-Wallis tests (SAS V9.2).Results: Of all the patients, 51.3% were male, average age was 67.1 +/- 12.7 years, and average disease duration was 9.9 +/- 9.1 years. More girls than boys were diagnosed during adolescence and more men than women during adulthood (20-60 years). No gender differences existed when age at diagnosis was >= 60 years. Patients were obese on average (BMI: 30.5+6.1 kg/m(2)) and had significantly higher BMI values than German population peers. The BMI gap was widest in the younger age categories and closed with increasing age. Adult women were significantly more obese than men. Obese patients more often had elevated HbA1c (>= 7.5%), hypertension or dyslipidemia (irrespective of age), microalbuminuria (adults), or retinopathy (elderly) than nonobese patients. More men than women (20-60 years) had hypertension, dyslipidemia, or microalbuminuria while more women than men (>= 60 years) had hypertension or dyslipidemia.Conclusion: During puberty, more girls than boys were diagnosed with T2DM while during adulthood males predominated. T2DM manifested at comparatively lower BMI in males, and younger patients were more obese at diagnosis. Age, gender, and BMI were also associated with poor metabolic control and cardiovascular disease comorbidities/complications.