Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly
Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly
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DOI：
10.1016/j.humimm.2006.10.019
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发表时间：
2007-02-01
期刊：
影响因子：
2.7
通讯作者：
Grubeck-Loebenstein, Beatrix
中科院分区：
文献类型：
--
作者：
Weinberger, Birgit;Lazuardi, Lutfan;Grubeck-Loebenstein, Beatrix
尽管普遍认为免疫学变化与衰老和巨细胞病毒（CMV）潜伏感染有关，但迄今为止，严格的年龄相关性变化和CMV诱导的变化之间没有明确的区别。因此，我们比较了CMV阳性（n = 164）和CMV阴性（n = 87）老年人中的CD 4（+）和CD 8（+）幼稚（CD 45 RA + CD 28+）、记忆（CD 45 RA-CD 28+）和效应（CD 28（-））T细胞，并将CD 8（+）和CD 4（+）效应T细胞与其他T细胞亚群相关联。与CMV阴性老年人相比，CMV阳性老年人中CD 8（+）和CD 4（+）效应T细胞的百分比较高，但幼稚和记忆细胞的百分比较低。发现在CMV阳性和CMV阴性的老年个体中，CD 8（+）T细胞亚群之间存在负相关。相反，CD 4（+）T细胞亚群内的相关性和CD 8（+）和CD 4（+）效应T细胞之间的正相关性仅在CMV阳性个体中发现。我们的研究结果表明：（a）在老年人中，不同的T细胞亚群在CD 8（+）T细胞群中竞争空间，但不是在CD 4（+）T细胞群中竞争空间;（B）CMV诱导的CD 4（+）区室的变化不同于在CMV阴性老年人中观察到的仅与年龄相关的变化;以及（c）在得出关于衰老对T细胞库组成的影响的结论之前，必须考虑群体的CMV状态。
Despite general acceptance that immunologic changes are associated with aging and latent infection with Cytomegalovirus (CMV), no clear-cut distinction has so far been made between strictly age-related and CMV-induced changes. We therefore compared CD4(+) and CD8(+) naive (CD45RA+CD28+), memory (CD45RA-CD28+), and effector (CD28(-)) T cells in CMV-positive (n = 164) and CMV-negative (n = 87) elderly persons and correlated CD8(+) and CD4(+) effector T cells with other T-cell subpopulations. Percentages of CD8(+) as well as CD4(+) effector T cells were higher, but percentages of naive and memory cells were lower in CMV-positive compared to CMV-negative elderly persons. Negative correlations within CD8(+) T-cell subsets were found to be present: in both CMV-positive and CMV-negative elderly individuals. In contrast, correlations within CD4(+) T-cell subpopulations and a positive correlation between CD8(+) and CD4(+) effector T cells were found in CMV-positive individuals only. Our results demonstrate that (a) in the elderly different T-cell subsets compete for space within the CD8(+), but not the CD4(+) T-cell population; (b) CMV induces changes in the CD4(+) compartment that differ from the solely age-related changes seen in CMV-negative elderly population; and (c) the CMV-status of a population has to be taken into account before a conclusion on the effect of aging on the composition of the T-cell pool can be reached.