Transitory Memory Retrieval in the Neural Networks Composed of Pinsky-Rinzel Model Neurons
Transitory Memory Retrieval in the Neural Networks Composed of Pinsky-Rinzel Model Neurons
复制标题
Pinsky-Rinzel 模型神经元组成的神经网络中的瞬时记忆检索
DOI：
10.1007/978-94-007-4792-0_91
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Ichiro Tsuda
中科院分区：
文献类型：
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作者：
Hiromichi Tsukada;Yutaka Yamaguti;Hiroshi Fujii;Ichiro Tsuda
人们提出了一种抽象的皮层记忆模型，即具有抑制性中间神经元的循环网络表现了记忆的连续检索。然而，这种行为是否出现在具有霍奇金-赫胥黎类型神经元的现实网络模型中，还没有得到澄清。通过使用由兴奋性神经元和抑制性中间神经元组成的现实模型，我们在这里表明，在生物学上合理的模型神经元网络中也观察到记忆的连续检索。生物学上，有证据表明乙酰胆碱（ACh）参与注意调节和胆碱能投射，降低大脑皮层第2/3层锥体神经元的ipsp。模拟结果表明，抑制性中间神经元的耦合强度对控制记忆检索状态至关重要；所有触发状态、记忆完成状态和连续记忆检索状态。在记忆检索的每个状态下，神经网络的场电位都有一个特定的频带。本文结合神经生理实验数据，讨论了抑制性中间神经元的耦合强度、记忆检索状态和频带特性的影响。
It has been proposed an abstract memory model of cortex that the recurrent network with inhibitory interneurons shows the successive retrieval of memories. It has not, however, been clarified whether such behavior appears in the realistic network model with the Hodgkin-Huxley type of neuron. By using the realistic model that consists of excitatory neurons and inhibitory interneurons, we here show that the successive retrieval of memories is also observed in the network of biologically-plausible model neurons.Biologically, there is evidence for the involvement of acetylcholine (ACh) in attentional modulation and cholinergic projection decreases IPSPs in pyramidal neurons in layer 2/3 of the cerebral cortex.Our simulation result shows that the coupling strength of inhibitory interneurons is very crucial for controlling the states of memory retrieval; all firing state, memory completion state and successive memory retrieval state. The field potential of the network in each state of memory retrieval has a specific frequency band. In this paper, we discuss the effects of the coupling strengths of inhibitory interneurons, the states of memory retrieval and the characteristics of frequency band in relation to the neurophysiological experimental data.