Transcriptional, post-transcriptional and epigenetic control of porcine oocyte maturation and embryogenesis.
Transcriptional, post-transcriptional and epigenetic control of porcine oocyte maturation and embryogenesis.
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DOI：
10.1530/biosciprocs.18.0017
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发表时间：
2020-10
期刊：
影响因子：
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通讯作者：
R. Prather;J. Ross;Isom S Clay;Jonathan A Green
中科院分区：
文献类型：
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作者：
R. Prather;J. Ross;Isom S Clay;Jonathan A Green
胚胎发生是一个复杂的过程，在各个层面上受到控制。随着关于控制其他物种发育的分子机制的新发现，显然这些相同的机制也调节猪的胚胎发生。 DNA 甲基化和组蛋白修饰调节转录，泛素化、自噬和 microRNA 等机制调节转录后发育。这些调节系统中的每一个在早期胚胎中都是高度动态的。更好地了解每个调控水平可以提供潜在地改善猪的繁殖过程、改进在体外创建猪胚胎和克隆胚胎的方法以及提供用于预测胚胎发育能力的标记的工具。
Embryogenesis is a complex process that is controlled at various levels. As new discoveries are made about molecular mechanisms that control development in other species, it is apparent that these same mechanisms regulate pig embryogenesis as well. Methylation of DNA and modification of histones regulate transcription, and mechanisms such as ubiquitinization, autophagy and microRNAs regulate development post-transcriptionally. Each of these systems of regulation is highly dynamic in the early embryo. A better understanding of each of these levels of regulation can provide tools to potentially improve the reproductive process in pigs, to improve methods of creating pig embryos and cloned embryos in vitro, and to provide markers for predicting developmental competence of the embryo.