The MyomiR network in skeletal muscle plasticity.
The MyomiR network in skeletal muscle plasticity.
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DOI：
10.1097/jes.0b013e31821c01e1
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发表时间：
2011-07
影响因子：
5.7
通讯作者：
McCarthy JJ
中科院分区：
文献类型：
--
作者：
McCarthy JJ
MicroRNA(MiRNA)是一类非编码RNA，通过转录后机制调控基因表达。基于我们实验室的工作，本综述探讨了一种假说，即最近描述的肌肉特异性miRNA，myomiR网络通过协调纤维类型和肌肉质量的变化来调节骨骼肌的可塑性，以响应改变的收缩活动。
MicroRNA (miRNA) are a class of noncoding RNA involved in regulating gene expression by a posttranscriptional mechanism. Based on work from our laboratory, this review explores the hypothesis that a recently described muscle-specific miRNA, myomiR, network has a central role in the regulation of skeletal muscle plasticity by coordinating changes in fiber type and muscle mass in response to altered contractile activity.