SYNERGISTIC INTERACTION BETWEEN EXERCISE AND INSULIN ON PERIPHERAL GLUCOSE-UPTAKE
SYNERGISTIC INTERACTION BETWEEN EXERCISE AND INSULIN ON PERIPHERAL GLUCOSE-UPTAKE
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DOI：
10.1172/jci110399
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发表时间：
1981-01-01
影响因子：
15.9
通讯作者：
FELIG, P
中科院分区：
文献类型：
--
作者：
DEFRONZO, RA;FERRANNINI, E;FELIG, P
在10名健康志愿者中，研究了运动和胰岛素对糖代谢的相互作用。使用了四种研究方案：研究1，血浆胰岛素升高约0.05。100 μ U/ml，同时血浆葡萄糖维持在基础水平2小时（胰岛素钳夹）;研究2，受试者在40% VO 2 max下进行30分钟自行车运动;研究3，按照研究1进行胰岛素钳夹（然而，在持续高胰岛素血症60分钟后，受试者按照研究2运动30分钟）;研究4，按照研究3对受试者进行研究，不同之处在于将导管插入股动脉和静脉以定量腿部葡萄糖摄入。在高胰岛素血症的60-90分钟期间（研究1），葡萄糖摄取平均为8.73 ± 0.05。0.10单独运动时（研究2），外周葡萄糖摄取的增量为1.43 ± 0.5mg/kg/min。0.30当高胰岛素血症和运动相结合时（研究3），葡萄糖摄取平均为15.06 ± 0.5mg/kg/min。0.98 mg/kg/min（P < 0.01），显著高于运动和胰岛素钳夹分别进行时的葡萄糖摄取量之和（P < 0.001）。葡萄糖摄取量的增加与下肢血流量的增加密切相关（r = 0.935，P < 0.001），提示这种协同作用是运动肌肉血流量增加和毛细血管表面积增加的结果。在研究1和3期间，超过85%的全身葡萄糖代谢由骨骼肌摄取占。胰岛素和运动协同作用以增强人体中的葡萄糖处置，并且肌肉是负责高胰岛素血症和运动后葡萄糖代谢增加的主要组织。
The interaction of exercise and insulin on glucose metabolism was examined in 10 healthy volunteers. Four study protocols were used: study 1, plasma insulin was raised by .apprx. 100 .mu.U/ml while plasma glucose was maintained at basal levels for 2 h (insulin clamp); study 2, subjects performed 30 min of bicycle exercise at 40% of VO2 max; study 3, an insulin clamp was performed as per study 1 (following 60 min of sustained hyperinsulinemia, however, subjects exercised for 30 min as per study 2); study 4, subjects were studied as per study 3 except that catheters were inserted into the femoral artery and vein to quantitate leg glucose uptake. During the 60-90 min period of hyperinsulinemia (study 1), glucose uptake averaged 8.73 .+-. 0.10 mg/kg per min. With exercise alone (study 2), the increment in peripheral glucose uptake was 1.43 .+-. 0.30 mg/kg per min. When hyperinsulinemia and exercise were combined (study 3), glucose uptake averaged 15.06 .+-. 0.98 mg/kg per min (P < 0.01), and this was significantly (P < 0.001) greater than the sum of glucose uptake when exercise and the insulin clamp were performed separately. The magnitude of rise in glucose uptake correlated closely with the increase in leg blood flow (r = 0.935, P < 0.001), suggesting that the synergism is the result of increased blood flow and increased capillary surface area to exercising muscle. More than 85% of total body glucose metabolism during studies 1 and 3 was accounted for by skeletal muscle uptake. Insulin and exercise act synergistically to enhance glucose disposal in man, and muscle is the primary tissue responsible for the increase in glucose metabolism following hyperinsulinemia and exercise.