Synthesis of (+/-)-epi-stegobinone utilizing silacyclopropanes as synthetic intermediates.
Synthesis of (+/-)-epi-stegobinone utilizing silacyclopropanes as synthetic intermediates.
复制标题
利用硅杂环丙烷作为合成中间体合成(i-)-表-stegobinone。
DOI：
10.1021/jo0620011
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Woerpel,KA
中科院分区：
文献类型：
--
作者：
Calad,StacieA;Cirakovic,Jelena;Woerpel,KA
以硅环丙烷衍生的二醇为原料，经10步反应合成了（±）-1 '-表-stegobinone，总收率17%。最终产物的所有立构中心相对于初始硅杂环丙烷的立体化学建立。该合成代表了第一次硅杂环丙烷反应性已被用于靶向合成。
The synthesis of (±)-1‘-epi-stegobinone has been accomplished in ten steps and 17% overall yield from a recently reported silacyclopropane-derived diol. All stereocenters of the final product were established relative to the stereochemistry of the initial silacyclopropane. This synthesis represents the first time silacyclopropane reactivity has been employed in a target-directed synthesis.