New Interleukins in Psoriasis and Psoriatic Arthritis Patients: The Possible Roles of Interleukin-33 to Interleukin-38 in Disease Activities and Bone Erosions
New Interleukins in Psoriasis and Psoriatic Arthritis Patients: The Possible Roles of Interleukin-33 to Interleukin-38 in Disease Activities and Bone Erosions
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银屑病和银屑病关节炎患者中的新型白细胞介素：白细胞介素 33 至白细胞介素 38 在疾病活动和骨侵蚀中的可能作用
DOI：
10.1159/000471798
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发表时间：
2017-01-01
期刊：
影响因子：
3.4
通讯作者：
Xue, Yu
中科院分区：
文献类型：
--
作者：
Li, Jiang;Liu, Lei;Xue, Yu
目的：新的白细胞介素（IL），特别是IL-1和IL-12家族的成员，最近被报道参与自身免疫性疾病和炎症性疾病的发展和调节。在这项研究中，我们的目的是探讨这些新的IL在银屑病（Ps）和银屑病关节炎（PsA）的影响。方法：40例PsA患者，20例Ps患者和20例健康对照（HC）。取血检测IL-12/23 p40、IL-12/23 p40、TNF-α水平。皮损的严重程度用皮损面积和严重程度指数（PASI）进行评估。采用关节活动指数（PsA Joint Activity Index）评价PsA患者的关节活动情况。对于PsA患者，评价了循环中破骨细胞生成相关细胞因子（骨保护素和核因子-κB配体的受体激活剂）和破骨细胞前体的数量。对这些患者受累关节的X线特征进行评分，包括侵蚀、关节间隙狭窄、骨质溶解和新骨形成。研究了这些IL、Ps和PsA水平与疾病活动和骨侵蚀之间的相关性。结果：Ps和PsA患者血清TNF-α、IL-12/23 p40和IL-33水平均高于正常对照组。PsA患者血清IL-34和IL-35水平高于Ps患者和HC。脓疱性Ps患者的血清IL-36α和IL-38水平高于寻常性Ps或HC患者。血清IL-36α水平升高与PASI呈正相关。结论：Ps和PsA患者循环中某些IL升高，这可能有助于皮肤病变和关节炎的发病。
Objectives: New interleukins (ILs), especially members of IL-1 and IL-12 families, have recently been reported to be involved in the development and regulation of autoimmune and inflammatory diseases. In this study, we aimed to explore the impact of these new ILs in psoriasis (Ps) and psoriatic arthritis (PsA). Methods: Forty PsA patients, 20 Ps patients, and 20 healthy controls (HCs) were recruited. Blood samples were obtained for detecting the levels of ILs, IL-12/23p40, and tumor necrosis factor α (TNF-α). The severity of skin lesions was assessed by the Psoriasis Area and Severity Index (PASI). Arthritis activities of PsA patients were assessed by the PsA Joint Activity Index. For PsA patients, circulating osteoclastogenesis-related cytokines (osteoprotegerin and receptor activator of nuclear factor-κB ligand) and numbers of osteoclast precursors were evaluated. Radiographic features of affected joints in these patients were scored for erosion, joint-space narrowing, osteolysis, and new bone formation. Correlations among levels of these ILs, Ps, and PsA disease activities and bone erosions were studied. Results: Ps and PsA patients had higher serum levels of TNF-α, IL-12/23p40, and IL-33. Serum levels of IL-34 and IL-35 were higher in PsA patients than in Ps patients and HCs. Patients with pustular Ps had higher serum levels of IL-36α and IL-38 than patients with Ps vulgaris or HCs. Increased serum levels of IL-36α were positively correlated with PASI. Conclusion: Certain ILs were elevated in the circulation of patients with Ps and PsA, which might contribute to the pathogenesis of skin lesions and arthritis.