The prognostic value of combined TGF-β1 and ELF in hepatocellular carcinoma.
The prognostic value of combined TGF-β1 and ELF in hepatocellular carcinoma.
复制标题
TGF-β1 与 ELF 联合检测对肝细胞癌的预后价值
DOI：
10.1186/s12885-015-1127-y
复制
发表时间：
2015-03-11
期刊：
影响因子：
3.8
通讯作者：
Hua YP
中科院分区：
文献类型：
--
作者：
Ji F;Fu SJ;Shen SL;Zhang LJ;Cao QH;Li SQ;Peng BG;Liang LJ;Hua YP
转化生长因子 (TGF-β) 信号通路的肿瘤抑制需要一种衔接蛋白——胚胎肝蛋白 (ELF)。 ELF 表达的破坏导致 Smad3 和 Smad4 的错误共定位，然后破坏 TGF-β 信号传导。然而，ELF 对肝细胞癌 (HCC) 的预后意义尚未明确。本研究旨在调查同时测量 TGF-β1 和 ELF 是否比单独使用任一标记物能够为 HCC 预后提供更强大的预测因子。免疫组化检测TGF-β1和ELF蛋白。分析TGF-β1/ELF表达与患者临床病理因素的关系。通过Kaplan-Meier曲线、对数秩检验和多元Cox回归分析分析TGF-β1/ELF表达与无病生存率和总生存率之间的关联。 HCC组织中TGF-β1的表达显着高于正常肝组织。相反，HCC组织中ELF的表达显着下降。 ELF蛋白与HBsAg、肿瘤大小、肿瘤数量、TNM和复发相关。数据还表明 ELF 和 TGF-β1 之间存在显着负相关。与TGF-β1低表达或/和ELF高表达的患者相比，TGF-β1高表达或/和ELF低表达的患者术后无病生存率和总生存率似乎较差。此外，ELF 与 TGF-β1 联合的预测范围比单独使用任何一种的预测范围更敏感。 TGF-β1和ELF蛋白是预测肝切除术后HCC患者预后的潜在且可靠的生物标志物。我们目前的研究表明，将它们结合起来可以提高测试的预后准确性。
Tumor suppression of Transforming Growth Factor (TGF-β) signaling pathway requires an adaptor protein, Embryonic Liver Fodrin (ELF). Disruption of ELF expression resulted in miscolocalization of Smad3 and Smad4, then disruption of TGF-β signaling. However, the prognostic significance of ELF for hepatocellular carcinoma (HCC) hasn’t been clarified. This study aimed to investigate whether measuring both TGF-β1 and ELF provides a more powerful predictor for HCC prognosis than either marker alone. TGF-β1 and ELF protein were detected by immunohistochemistry. The relationship between TGF-β1/ELF expression and patients’ clinicopathologic factors was analyzed. The association between TGF-β1/ELF expression and disease-free survival and overall survival was analyzed by Kaplan-Meier curves, the log-rank test, and Multivariate Cox regression analyses. The expression of TGF-β1 in HCC tissues was significantly higher than that in normal liver tissues. Conversely, the expression of ELF in HCC tissues declined markedly. ELF protein was correlated with HBsAg, tumor size, tumor number, TNM and recurrence. Data also indicated a significant negative correlation between ELF and TGF-β1. Patients with high TGF-β1 expression or/and low ELF expression appeared to have a poor postoperative disease-free survival and overall survival compared with those with low TGF-β1 expression or/and high ELF expression. Furthermore, the predictive range of ELF combined with TGF-β1 was more sensitive than that of either one alone. TGF-β1 and ELF protein are potential and reliable biomarkers for predicting prognosis in HCC patients after hepatic resection. Our current study has demonstrated that the prognostic accuracy of testing can be enhanced by their combination.
登录
查看更多内容
DOI：
10.1016/j.bbrc.2006.03.236
发表时间：
2006-06-16
影响因子：
3.1
作者：
Kim, Sang Soo;Shetty, Kirti;Mishra, Lopa
通讯作者：
Mishra, Lopa
影响因子：
3.5
作者：
Kim, Do Young;Paik, Yong Han;Han, Kwang Hyub
通讯作者：
Han, Kwang Hyub
影响因子：
7.2
作者：
Moses, Harold;Barcellos-Hoff, Mary Helen
通讯作者：
Barcellos-Hoff, Mary Helen
影响因子：
8
作者：
Kitisin, K.;Ganesan, N.;Mishra, L.
通讯作者：
Mishra, L.
影响因子：
13
作者：
Bierie, Brian;Moses, Harold L.
通讯作者：
Moses, Harold L.