Pyrimidine-Psoralen-Pyrimidine Photodiadducts from DNA
Pyrimidine-Psoralen-Pyrimidine Photodiadducts from DNA
复制标题
DNA 中的嘧啶-补骨脂素-嘧啶光二加合物
DOI：
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发表时间：
1982
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通讯作者：
H. Rapoport
中科院分区：
文献类型：
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作者：
D. Kanne;K. Straub;J. Hearst;H. Rapoport
We report the isolation and characterization for the first time of pyrimidine-psoralen-pyrimidine photodiadducts from DNA. For each of the four psoralens studied, a single pair of diastereomeric thymidine-psoralen-thymidine photcdiadducts, each with cis-syn stereochemistry, was found to account for >90% of the diadducts formed. In addition, we have carried out pulse-chase experiments that establish that these photo cross-links are formed by cycloaddition of a second thymidine residue to the 3,4 double bond (pyrone side) of an initially formed 4',5' (furan-side) psoralen-thymidine photomonoadduct.
