Hypercomplementemia at relapse in patients with anti-aquaporin-4 antibody
Hypercomplementemia at relapse in patients with anti-aquaporin-4 antibody
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DOI：
10.1177/1352458508099139
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发表时间：
2009-03-01
影响因子：
5.8
通讯作者：
Kira, J. I.
中科院分区：
文献类型：
--
作者：
Doi, H.;Matsushita, T.;Kira, J. I.
目的由于亚洲视神经脊髓型多发性硬化（OSMS）患者经常出现抗水通道蛋白4（AQP 4）抗体，补体介导的星形胶质细胞足突破坏被提出，但尚未得到证实。我们的目的是澄清是否补体消耗发生在复发抗AQP 4抗体阳性patients.Methods我们分析了血清CH 50，C3，C4，和C-反应蛋白（CRP）水平和它们的关系，在118 MS患者的临床阶段或不抗AQP 4抗体。24例有抗AQP 4抗体的患者在复发时血清CH 50水平高于39例OSMS和54例无抗AQP 4抗体的常规形式MS（CMS）患者（P-corr < 0.05），但在缓解期则无。抗AQP 4抗体阳性的CMS患者复发时高补体血症的发生率也高于抗AQP 4抗体阴性的CMS患者（70.4%vs29.0%，P-corr < 0.05）。复发时三组之间的C3和C4水平没有显着差异。在抗AQP 4抗体阳性的患者中，高补体血症和高CRP同时存在的情况在复发期较缓解期多见（36.0% vs10.5%，P < 0.05）。在中枢神经系统广泛病变患者中，抗AQP 4抗体阳性者高补体血症发生率明显高于抗AQP 4抗体阴性者（88.9% vs16.7%，P < 0.01）。我们认为，高补体血症在抗AQP 4抗体阳性患者可能反映了全身炎症反应复发。多发性硬化2009; 15：304-310. http://msj.sagepub.com
Objective Because Asian patients with opticospinal multiple sclerosis (OSMS) frequently have anti-aquaporin-4 (AQP4) antibody, complement-mediated disruption of astrocyte foot processes is proposed but not yet proven. We aimed to clarify whether complement consumption occurs at relapse in anti-AQP4 antibody-positive patients.Methods We analyzed serum CH50, C3, C4, and C-reactive protein (CRP) levels and their relation to clinical phases in 118 MS patients with or without anti-AQP4 antibody. Serum CH50 levels were higher in 24 patients with anti-AQP4 antibody than in 39 OSMS and 54 conventional form of MS (CMS) patients without anti-AQP4 antibody at relapse (P-corr < 0.05) but not in remission. The frequency of hypercomplementemia at relapse was also higher in anti-AQP4 antibody-positive patients than in anti-AQP4 antibody-negative CMS patients (70.4% vs 29.0%, P-corr < 0.05). C3 and C4 levels did not differ significantly among the three groups at relapse. In patients with anti-AQP4 antibody, the coexistence of hypercomplementemia and high CRP values was more common at relapse than in the remission phase (36.0% vs 10.5%, P < 0.05). In patients with extensive central nervous system lesions, hypercomplementemia was significantly more common in anti-AQP4 antibody-positive patients than anti-AQP4 antibody-negative ones (88.9% vs 16.7%, P < 0.01). We consider that hypercomplementemia in anti-AQP4 antibody-positive patients may reflect a systemic inflammatory reaction at relapse. Multiple Sclerosis 2009; 15: 304-310. http://msj.sagepub.com