Effects of adrenalectomy and chronic adrenal corticosteroid replacement on potassium transport in rat kidney.
Effects of adrenalectomy and chronic adrenal corticosteroid replacement on potassium transport in rat kidney.
复制标题
肾上腺切除术和慢性肾上腺皮质类固醇替代对大鼠肾脏钾转运的影响。
DOI：
--
复制
发表时间：
1985
影响因子：
15.9
通讯作者：
R. DeFronzo
中科院分区：
文献类型：
--
作者：
B. Stanton;G. Giebisch;G. Klein;J. Wade;R. DeFronzo
通过结对喂养大鼠进行清除实验，观察肾上腺切除术和生理量选择性肾上腺皮质类固醇替代对肾钾转运的长期影响。为此，在假手术或肾上腺切除（ADX）的大鼠中进行了清除率研究。ADX动物分别通过渗透微型泵给予醛固酮（0.5微克/100克体重/天）、地塞米松（1.2微克/100克体重/天）或醛固酮和地塞米松，持续7-9天，然后进行清除实验。在慢性激素治疗后，在仅输注林格液的基础条件下，所有组的钾排泄量相似。然而，在所有没有矿化皮质激素替代的ADX动物中，尿钾排泄维持在控制水平与高钾血症、尿流量增加和尿钠有关；这些都是已知的刺激尿钾排泄的因素。急性输钾时，ADX大鼠尿钾排泄量的增加比对照组少。地塞米松部分纠正了钾排泄的功能性缺陷，并与尿流量显著增加一致。替代醛固酮或醛固酮与地塞米松长期联合给予，钾排泄量急剧增加，但不能恢复到控制水平。在慢性醛固酮和地塞米松治疗的基础上，仅急性醛固酮输注（0.2微克/100克体重/小时，外加0.2微克/100克体重/小时）可使钾排泄完全恢复到控制水平。醛固酮诱导的慢性和急性钾排泄增强与高钾血症、尿流增加或尿钠无关。因此，两类肾上腺皮质激素的生理水平刺激肾钾排泄，尽管机制不同。矿化皮质激素直接刺激肾小管钾的排泄，而糖皮质激素通过增加沿远端肾元的液体和钠的输送间接增加排泄。
Clearance experiments were carried out in pair-fed rats to examine the long-term effects of adrenalectomy and selective adrenal corticosteroid replacement in physiological amounts on renal potassium transport. To this end, clearance studies were conducted in rats that were sham operated, or adrenalectomized (ADX). ADX animals were given either vehicle, aldosterone (0.5 microgram/100 g body wt per day), dexamethasone (1.2 micrograms/100 g body wt per day), or aldosterone and dexamethasone, by osmotic minipump for 7-9 d whereupon clearance experiments were conducted. After chronic hormone treatment, during basal conditions when only Ringers solution was infused, all groups excreted similar amounts of potassium. However, in all ADX animals without mineralocorticoid replacement, the maintenance of urinary potassium excretion at control levels was associated with hyperkalemia, increased urine flow, and natriuresis; all are factors known to stimulate urinary potassium excretion. During acute potassium infusion, the increase in urinary potassium excretion was less in ADX rats than in controls. This functional deficiency in potassium excretion was partially corrected by dexamethasone and was uniformly associated with a significant increase in urine flow. Aldosterone replacement or aldosterone and dexamethasone given together chronically, sharply increased potassium excretion but did not restore excretion to control levels. Only acute aldosterone infusion (0.2 microgram/100 g body wt bolus plus 0.2 microgram/100 g body wt per hour), superimposed upon chronic aldosterone and dexamethasone treatment, fully restored potassium excretion to control levels. This aldosterone induced enhancement of potassium excretion, both chronic and acute, was not associated with hyperkalemia, and increased urine flow or natriuresis. Thus, physiological levels of both classes of adrenal corticosteroids stimulate renal potassium excretion albeit by different mechanisms. Mineralocorticoids stimulate tubular potassium excretion directly, whereas glucocorticoids augment excretion indirectly by increasing fluid and sodium delivery along the distal nephron.
登录
查看更多内容
急性矿物皮质类固醇和糖皮质激素给药对肾酸消除的不同影响。
影响因子：
19.6
作者：
Wilcox,CS;Cemerikic,DA;Giebisch,G
通讯作者：
Giebisch,G
肾上腺类固醇对大鼠肾 Na -K -ATP 酶的调节。
DOI：
10.1152/ajprenal.1981.241.2.f186
发表时间：
1981
期刊：
The American journal of physiology
影响因子：
--
作者：
Rodriguez,HJ;Sinha,SK;Starling,J;Klahr,S
通讯作者：
Klahr,S
醛固酮的肾脏靶位点和作用机制。
DOI：
--
发表时间：
1983
期刊：
Mineral and electrolyte metabolism
影响因子：
--
作者：
Marver,D;Kokko,JP
通讯作者：
Kokko,JP
兔集合管的异质性：盐皮质激素作用于皮质部分的定位。
影响因子：
19.6
作者：
Stokes,JB;Ingram,MJ;Williams,AD;Ingram,D
通讯作者：
Ingram,D
影响因子：
19.6
作者：
B. Stanton;D. Biemesderfer;J. Wade;G. Giebisch
通讯作者：
B. Stanton;D. Biemesderfer;J. Wade;G. Giebisch