Myocardial blood flow reserve assessed by positron emission tomography myocardial perfusion imaging identifies patients with a survival benefit from early revascularization
Myocardial blood flow reserve assessed by positron emission tomography myocardial perfusion imaging identifies patients with a survival benefit from early revascularization
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DOI：
10.1093/eurheartj/ehz389
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发表时间：
2020-02-07
影响因子：
39.3
通讯作者：
Bateman, Timothy M.
中科院分区：
文献类型：
--
作者：
Patel, Krishna K.;Spertus, John A.;Bateman, Timothy M.
目的正电子发射断层扫描（PET）心肌灌注成像（MPI）可以无创测量心肌血流储备（MBFR）。我们的目的是研究MBFR是否能识别出血运重建术后患者的生存获益，从而帮助指导试验后的管理。方法和结果我们研究了2010年1月至2016年12月期间12594例连续接受Rb-82休息/应激PET MPI的患者的全因死亡率，排除了心肌病、既往冠状动脉搭桥手术（CABG）和MBFR缺失的患者。心肌血流量储备计算为应激与休息绝对心肌血流量之比。Cox模型调整患者和试验特征，早期血运重建术（经皮冠状动脉介入治疗或CABG） = 10%缺血。平均MBFR为2.01.3，与MBFR
Aims Positron emission tomography (PET) myocardial perfusion imaging (MPI) can non-invasively measure myocardial blood flow reserve (MBFR). We aimed to examine whether MBFR identifies patients with a survival benefit after revascularization, helping to guide post-test management.Methods and results We examined all-cause mortality in 12594 consecutive patients undergoing Rb-82 rest/stress PET MPI from January 2010 to December 2016, after excluding those with cardiomyopathy, prior coronary artery bypass surgery (CABG), and missing MBFR. Myocardial blood flow reserve was calculated as the ratio of stress to rest absolute myocardial blood flow. A Cox model adjusted for patient and test characteristics, early revascularization (percutaneous coronary intervention or CABG = 10% ischaemia. Mean MBFR was 2.01.3, with MBFR