Mechanistic targets and phytochemical strategies for breaking the obesity-cancer link.
Mechanistic targets and phytochemical strategies for breaking the obesity-cancer link.
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DOI：
10.3389/fonc.2013.00209
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发表时间：
2013
影响因子：
4.7
通讯作者：
Hursting SD
中科院分区：
文献类型：
--
作者：
Ford NA;Lashinger LM;Allott EH;Hursting SD
肥胖症是许多癌症的既定风险和进展因素，过去三十年来在许多国家急剧增加。据估计，全球目前有6亿成年人肥胖。因此，迫切需要更好地了解肥胖和癌症之间的机制联系，以确定干预目标和策略，以抵消肥胖的促癌效应。这篇综述综合了肥胖与癌症相关的关键生物学机制的证据，特别强调了肥胖相关的生长因子信号传导、炎症和肿瘤微环境扰动的增强。这些在肥胖个体中异常调节的相互关联的途径和过程代表了使用植物化学物质破坏肥胖-癌症联系的基于机制的目标。
The prevalence of obesity, an established risk and progression factor for many cancers, has increased dramatically in many countries over the past three decades. Worldwide, an estimated 600 million adults are currently obese. Thus, a better understanding of the mechanistic links between obesity and cancer is urgently needed to identify intervention targets and strategies to offset the procancer effects of obesity. This review synthesizes the evidence on key biological mechanisms underlying the obesity-cancer association, with particular emphasis on obesity-associated enhancements in growth factor signaling, inflammation, and perturbations in the tumor microenvironment. These interrelated pathways and processes that are aberrantly regulated in obese individuals represent mechanism-based targets for disrupting the obesity-cancer link using phytochemicals.