Cancer gene therapy: scientific basis.
Cancer gene therapy: scientific basis.
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DOI：
10.1146/annurev.med.53.082901.104039
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发表时间：
2002
影响因子：
10.5
通讯作者：
P. Wadhwa;S. Zielske;Justin C. Roth;C. Ballas;J. E. Bowman;S. Gerson
中科院分区：
文献类型：
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作者：
P. Wadhwa;S. Zielske;Justin C. Roth;C. Ballas;J. E. Bowman;S. Gerson
肿瘤基因治疗是近十年来肿瘤治疗研究中最令人兴奋和最令人难以捉摸的领域之一。在靶向癌细胞、癌脉管系统、免疫系统和骨髓的基因治疗中已经出现了关键的发展，骨髓本身通常是治疗剂的严重毒性的靶点。我们回顾了该领域的一些最新进展。在每种情况下，明确的临床前模型验证了治疗方法，并努力在临床前和早期临床试验中评估目标影响。尽管目前的癌症基因疗法无法持续治愈癌症，但快速的进展可能意味着这种治愈方法只需要短短几年的时间。
Gene therapy of cancer has been one of the most exciting and elusive areas of therapeutic research in the past decade. Critical developments have occurred in gene therapy targeting cancer cells, cancer vasculature, the immune system, and the bone marrow, itself often the target for severe toxicity from therapeutic agents. We review some recent developments in the field. In each instance, clear preclinical models validated the therapeutic approach and efforts have been made to evaluate the target impact in both preclinical and early clinical trials. Although no cures can consistently be expected from today's cancer gene therapy, the rapid progress may imply that such cures are a few short years away.