Obesity, recreational physical activity, and risk of pancreatic cancer in a large US cohort
Obesity, recreational physical activity, and risk of pancreatic cancer in a large US cohort
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DOI：
10.1158/1055-9965.epi-04-0583
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发表时间：
2005-02-01
影响因子：
3.8
通讯作者：
Calle, EE
中科院分区：
文献类型：
--
作者：
Patel, AV;Rodriguez, C;Calle, EE
背景资料：肥胖和体力活动，部分通过其对胰岛素敏感性的影响，可能是可改变的危险因素胰腺癌。方法：作者分析了美国癌症协会癌症预防研究II营养队列的数据，研究肥胖，娱乐性体力活动，胰腺癌的风险之间的关联措施。1992年，通过对145，627名在入组时无癌症的男性和女性进行自填式问卷调查，在基线时获得了关于当前体重和18岁时体重、体重增加的位置和娱乐性体力活动的信息。在7年的随访中，在这些参与者中确定了242例胰腺癌病例。采用考克斯比例风险模型计算风险率比（RR），并调整潜在的混杂因素，包括个人糖尿病史和吸烟史。我们观察到肥胖[体重指数（BMI）> 30]的男性和女性与正常BMI [每周31.5代谢当量小时]的男性和女性相比，胰腺癌的风险增加结论：本研究沿着近年来的一些研究，支持肥胖和中心性肥胖与胰腺癌风险相关的假设。
Background: Obesity and physical activity, in part through their effects on insulin sensitivity, may be modifiable risk factors for pancreatic cancer.Methods: The authors analyzed data from the American Cancer Society Cancer Prevention Study II Nutrition Cohort to examine the association between measures of adiposity, recreational physical activity, and pancreatic cancer risk. Information on current weight and weight at age 18, location of weight gain, and recreational physical activity were obtained at baseline in 1992 via a self-administered questionnaire for 145,627 men and women who were cancer-free at enrollment. During the 7 years of follow-up, 242 incident pancreatic cancer cases were identified among these participants. Cox proportional hazards modeling was used to compute hazard rate ratios (RR) and to adjust for potential confounding factors including personal history of diabetes and smoking.Results: We observed an increased risk of pancreatic cancer among obese [body mass index (BMI) > 30] men and women compared with men and women of normal BMI [31.5 metabolic equivalent hours per week) at baseline compared with men and women who reported no recreational physical activity (RR, 1.20; 95% CI, 0.63-2.27).Conclusion: This study, along with several recent studies, supports the hypothesis that obesity and central adiposity are associated with pancreatic cancer risk.