Glyceryl tribenzoate: A food additive with unique properties to be a substitute for cinnamon.
Glyceryl tribenzoate: A food additive with unique properties to be a substitute for cinnamon.
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DOI：
10.33140/jcei.06.05.04
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Pahan K
中科院分区：
文献类型：
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作者：
Pahan S;Dasarathi S;Pahan K
肉桂是一种经常使用的天然调味料和调味料在世界各地的时代。最近的实验室研究表明，口服肉桂可能有益于不同的神经炎症和神经退行性疾病，如多发性硬化症（MS），帕金森病（PD），阿尔茨海默病（AD）和路易体病（LBD）。然而，肉桂的某些局限性（例如，在世界各地无法获得真正的锡兰肉桂，肉桂粉中的杂质等）。已经引起了研究人员的兴趣，以寻找肉桂的替代品，可以在上述疾病中提供相同的疗效。甘油三苯甲酸酯（GTB）是美国食品和药物管理局（FDA）批准的调味剂成分，用于食品和食品包装行业。已经发现，类似于肉桂，口服GTB能够上调调节性T细胞并抑制实验性自身免疫性脑脊髓炎（MS的动物模型）的自身免疫性疾病过程。此外，GTB和肉桂代谢物苯甲酸钠（NaB）都具有减弱亨廷顿病（HD）的小鼠模型中的神经变性病理的效力。在这里，我们还证明了GTB在星形胶质细胞和巨噬细胞中的抗炎特性，肉桂及其代谢物苯甲酸钠（NaB）也具有这种特性。因此，在这里，我们真诚地尝试讨论肉桂和GTB之间的相似之处和不同之处，重点是GTB是否有可能被认为是肉桂的替代品，用于神经炎症和神经退行性疾病。
Cinnamon is a regularly used natural seasoning and flavoring material throughout the world for eras. Recent laboratory studies have demonstrated that oral cinnamon may be beneficial for different neuroinflammatory and neurodegenerative disorders such as multiple sclerosis (MS), Parkinson’s disease (PD), Alzheimer’s disease (AD), and Lewy body diseases (LBD). However, cinnamon’s certain limitations (e.g. unavailability of true Ceylon cinnamon throughout the world, impurities in ground cinnamon, etc.) have initiated an interest among researchers to find an alternate of cinnamon that can potentially deliver the same efficacy in the diseases mentioned above. Glyceryl tribenzoate (GTB) is a U.S. Food and Drug Administration (FDA)-approved flavoring ingredient that is used in food and food packaging industries. It has been found that similar to cinnamon, oral GTB is capable of upregulating regulatory T cells and suppressing the autoimmune disease process of experimental autoimmune encephalomyelitis, an animal model of MS. Moreover, both GTB and cinnamon metabolite sodium benzoate (NaB) have the potency to attenuate neurodegenerative pathology in a mouse model of Huntington disease (HD). Here, we have also demonstrated anti-inflammatory property of GTB in astrocytes and macrophages, a property that is also seen with cinnamon and its metabolite sodium benzoate (NaB). Therefore, here, we have made a sincere attempt to discuss the similarities and dissimilarities between cinnamon and GTB with a focus whether GTB has the potential to be considered as a substitute of cinnamon for neuroinflammatory and neurodegenerative disorders.