Distribution and developmental change in [3H]MK-801 binding within zebra finch song nuclei.
Distribution and developmental change in [3H]MK-801 binding within zebra finch song nuclei.
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斑胸草雀鸣声核内 [3H]MK-801 结合的分布和发育变化。
DOI：
10.1002/neu.480230806
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Nordeen,KW
中科院分区：
文献类型：
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作者：
Aamodt,SM;Kozlowski,MR;Nordeen,EJ;Nordeen,KW
在许多鸣禽中，发声学习依赖于敏感期内适当的听觉体验，这与与歌曲相关神经通路的形成和重组相一致。由于早期感觉经验对神经组织和早期学习的一些影响与N-甲基-d-天冬氨酸（NMDA）受体的激活有关，我们测量了控制斑胸草雀鸣唱行为的神经系统内与该受体的结合。定量放射自显影用于测量成年和幼年雄性斑胸草雀脑中非竞争性拮抗剂[3 H]MK-801（地佐环平）的结合，重点关注与歌曲学习和产生有关的四个端脑区域。总体而言，斑胸草雀中MK-801的结合模式与大鼠中发现的模式相似（Monaghan和Cotman，1985，J. Neurosci.5：2909-2919; Sakurai，Cha，Penney和Young，1991，Neuroscience 40：533-543）。也就是说，端脑中的结合最高，丘脑区域居中，脑干和小脑几乎不存在。端脑的歌曲领域表现出中间水平的结合，并结合在青少年没有显着不同的成年人的水平，在大多数的歌曲核。然而，在外侧大细胞核的前新纹状体（IMAN），结合在30日龄显着高于结合在成人。鉴于NMDA受体在其他发育中的神经系统中的既定作用，它们在歌曲控制核团中的存在及其在歌曲学习中涉及的区域内的发育调节表明，NMDA受体在调节听觉体验对歌曲行为发展的影响中发挥作用。
In many songbirds, vocal learning depends upon appropriate auditory experience during a sensitive period that coincides with the formation and reorganization of song‐related neural pathways. Because some effects of early sensory experience on neural organization and early learning have been linked to activation ofN‐methyl‐d‐aspartate (NMDA) receptors, we measured binding to this receptor within the neural system controlling song behavior in zebra finches. Quantitative autoradiography was used to measure binding of the noncompetitive antagonist [3H]MK‐801 (dizocilpine) in the brains of both adult and juvenile male zebra finches, focusing on four telencephalic regions implicated in song learning and production. Overall, the pattern of MK‐801 binding in zebra finches was similar to the pattern found in rats (Monaghan and Cotman, 1985,J. Neurosci.5:2909–2919; Sakurai, Cha, Penney, and Young, 1991,Neuroscience40:533–543). That is, binding was highest in the telencephalon, intermediate in thalamic regions, and virtually absent from the brain stem and cerebellum. The telencephalic song areas exhibited intermediate levels of binding, and binding in the juveniles was not significantly different from adult levels in most song nuclei. However, in the lateral magnocellular nucleus of the anterior neostriatum (IMAN), binding at 30 days of age was significantly higher than binding in adults. Given the established role of NMDA receptors in other developing neural systems, both their presence in song control nuclei and their developmental regulation within a region implicated in song learning suggest that NMDA receptors play a role in mediating effects of auditory experience on the development of song behavior.