SLC39A4 expression is associated with enhanced cell migration, cisplatin resistance, and poor survival in non-small cell lung cancer.
SLC39A4 expression is associated with enhanced cell migration, cisplatin resistance, and poor survival in non-small cell lung cancer.
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DOI：
10.1038/s41598-017-07830-4
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发表时间：
2017-08-03
影响因子：
4.6
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Wu DM;Liu T;Deng SH;Han R;Xu Y
锌转运蛋白SLC39A4在多种肿瘤中影响上皮细胞的形态和迁移，但其在肺癌细胞侵袭和化疗耐药中的作用尚不清楚。在此，对非小细胞肺癌基因表达的综合分析显示，SLC39A4的表达与肿瘤大小、区域淋巴转移、总生存期(OS)和无瘤生存期(DFS)缩短显著相关。慢病毒介导的shRNA沉默SLC39A4在体内外分别阻断了人肺癌细胞上皮-间充质转化和转移。此外，SLC39A4基因敲除通过抑制肺癌细胞的干性而增强了癌细胞对顺铂诱导的死亡的敏感性。总之，这些数据提示SLC39A4可能成为非小细胞肺癌肿瘤转移的新的治疗靶点和预测标记物。
The zinc transporter SLC39A4 influences epithelial cell morphology and migration in various cancers; however, its role in regulating cell invasion and chemotherapeutic resistance in human lung cancer is not yet clear. Here, integrated analysis of gene expression in non-small cell lung cancer revealed that SLC39A4 expression is significantly correlated with increased tumour size and regional lymph node spread, as well as shorter overall survival (OS) and disease-free survival (DFS). SLC39A4 silencing by lentivirus-mediated shRNA blocked human lung cancer cell epithelial-mesenchymal transition and metastasis in vitro and in vivo, respectively. Moreover, SLC39A4 knockdown enhanced cancer cell sensitivity to cisplatin-induced death by inhibiting stemness in lung cancer cells. Collectively, these data suggest that SLC39A4 may be a novel therapeutic target and predictive marker of tumour metastasis in non-small cell lung cancer.
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