CONTROL OF GAMETE FORMATION (EXFLAGELLATION) IN MALARIA PARASITES
CONTROL OF GAMETE FORMATION (EXFLAGELLATION) IN MALARIA PARASITES
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DOI：
10.1126/science.12566
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发表时间：
1977-01-01
期刊：
影响因子：
56.9
通讯作者：
NIJHOUT, MM
中科院分区：
文献类型：
--
作者：
CARTER, R;NIJHOUT, MM
疟疾寄生虫能够在蚊子中建立感染的唯一阶段是在脊椎动物宿主血液中循环的配子体。在蚊子摄入后的几分钟内，配子体在出鞭毛的过程中转化为成熟的配子。这个过程在体外（在鸡疟原虫中）仅通过血液从循环环境移动到大气环境时血液pH值的变化来控制，当血液与大气平衡时，pH值的升高由CO2张力的下降介导。
The only stages of malaria parasites capable of establishing an infection in a mosquito are the gametocytes that circulate in the blood of the vertebrate host. Within minutes of ingestion by a mosquito the gametocytes transform into mature gametes in the process of exflagellation. This process is controlled in vitro [in Plasmodium gallinaceum; the chicken malaria parasite] solely by the change in blood pH as it moves from the environment of the circulation to that of the atmosphere, the pH rise being mediated by the fall in CO2 tension as the blood equilibrates with the atmosphere.