Combined effect of mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on estimated glomerular filtration rate in male Japanese health check-up examinees: a cross-sectional study.
Combined effect of mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on estimated glomerular filtration rate in male Japanese health check-up examinees: a cross-sectional study.
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DOI：
10.1186/1471-2369-14-35
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发表时间：
2013-02-12
期刊：
影响因子：
2.3
通讯作者：
Takashima Y
中科院分区：
文献类型：
--
作者：
Kokaze A;Ishikawa M;Matsunaga N;Karita K;Yoshida M;Shimada N;Ohtsu T;Shirasawa T;Ochiai H;Hoshino H;Takashima Y
预防慢性肾脏病（CKD）是一个重大的公共卫生问题。尽管已经进行了几项关于饮酒与 CKD 或肾功能之间关系的研究，但仍存在争议。据报道，许多遗传多态性与 CKD 和肾功能有关。线粒体 DNA 胞嘧啶/腺嘌呤 (Mt5178 C/A) 多态性与日本人的长寿有关。这种多态性改变了饮酒对血压、高血压风险、血清甘油三酯水平、高低密度脂蛋白胆固醇血症风险和血清尿酸水平的影响。本研究的目的是调查 Mt5178 C/A 多态性是否改变饮酒对日本男性健康检查受试者肾功能的影响。从定期到医院进行体检的个体中选取了 394 名年龄在 29 岁至 76 岁之间的男性受试者。 Mt5178 C/A 基因分型后，进行了一项横断面研究，评估 Mt5178 C/A 多态性和习惯性饮酒对估计肾小球滤过率 (eGFR) 轻度下降 (<90ml/min/1.73m2) 风险的综合影响。对于 Mt5178A 基因型男性，习惯性饮酒可能会增加 eGFR（趋势 P = 0.003）或降低 eGFR 轻度下降的风险（趋势 P = 0.003）。每天饮酒者的 eGFR 显着高于不饮酒者 (P = 0.005)。每日饮酒者 eGFR 降低的粗比值比显着低于不饮酒者（比值比 = 0.092，95% 置信区间：0.012-0.727，P = 0.024）。另一方面，对于 Mt5178C 基因型男性来说，习惯性饮酒似乎不会影响 eGFR。目前的结果表明，Mt5178 C/A 多态性和饮酒对 eGFR 的共同影响以及日本男性受试者 eGFR 轻度下降的风险。
Prevention of chronic kidney disease (CKD) is a major public health issue. Although several studies have been performed on the association between alcohol consumption and CKD or renal function, it remains controversial. Numerous genetic polymorphisms have been reported to be associated with CKD and kidney function. Mitochondrial DNA cytosine/adenine (Mt5178 C/A) polymorphism is associated with longevity in Japanese. This polymorphism modifies the effects of alcohol consumption on blood pressure, risk of hypertension, serum triglyceride levels, risk of hyper-LDL cholesterolemia and serum uric acid levels. The objective of this study was to investigate whether Mt5178 C/A polymorphism modifies the effects of alcohol consumption on renal function in male Japanese health check-up examinees. A total of 394 male subjects aged 29–76 years were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the combined effects of Mt5178 C/A polymorphism and habitual drinking on the risk of mildly decreased estimated glomerular filtration rate (eGFR) (<90 ml/min/1.73 m2) was conducted. For Mt5178A genotypic men, habitual drinking may increase eGFR (P for trend = 0.003) or reduce the risk of mildly decreased eGFR (P for trend = 0.003). Daily drinkers had a significantly higher eGFR than non-drinkers (P = 0.005). The crude odds ratio for decreased eGFR was significantly lower in daily drinkers than in non-drinkers (odds ratio = 0.092, 95% confidence interval: 0.012-0.727, P = 0.024). On the other hand, for Mt5178C genotypic men, habitual drinking does not appear to affect eGFR. The present results suggest a joint effect of Mt5178 C/A polymorphism and alcohol consumption on eGFR and the risk of mildly decreased eGFR in male Japanese subjects.