Prevalence of RHD alleles in Japanese individuals with weak D phenotype: Identification of 20 new RHD alleles
Prevalence of RHD alleles in Japanese individuals with weak D phenotype: Identification of 20 new RHD alleles
复制标题
DOI：
10.1111/vox.12413
复制
发表时间：
2016-05
期刊：
影响因子：
2.7
通讯作者：
K. Isa;K. Sasaki;K. Ogasawara;M. Saito;H. Tsuneyama;R. Yabe;M. Uchikawa;M. Satake
中科院分区：
文献类型：
--
作者：
K. Isa;K. Sasaki;K. Ogasawara;M. Saito;H. Tsuneyama;R. Yabe;M. Uchikawa;M. Satake
我们从226名弱D表型的日本人中鉴定出46个不同的RHD等位基因，其中26个已被描述，20个为新发现。在这些弱D个体中，C.960G>；A、C.845G>；A(RHD*15)和C.1013T>；C(RHD*01W.24)突变的等位基因最常见，相对发生率分别为36.7%、15.9%和9.7%。这些发现表明，日本人群中常见的弱D等位基因的患病率明显不同于高加索人群。
We identified 46 different RHD alleles from 226 Japanese individuals with weak D phenotype, 26 of which had been previously described and 20 that were novel. Among these weak D individuals, the alleles with c.960G>A, c.845G>A (RHD*15) or c.1013T>C (RHD*01W.24) mutations were most prevalent with relative occurrences of 36·7%, 15·9% and 9·7%, respectively. These findings demonstrate that the prevalence of common weak D alleles in the Japanese population significantly differs from that of Caucasian populations.