Flavonoids from Iris songarica and their Antioxidant and Estrogenic Activity
Flavonoids from Iris songarica and their Antioxidant and Estrogenic Activity
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DOI：
10.1055/s-2008-1081342
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发表时间：
2008-10-01
期刊：
影响因子：
2.7
通讯作者：
Khan, Ikhlas A.
中科院分区：
文献类型：
--
作者：
Moein, Mahmood R.;Khan, Shabana I.;Khan, Ikhlas A.
从鸢尾根茎和根中分离得到新的二氢黄酮醇、松香脂醇(1)和7个已知的类黄酮，分别为虫胺素A(2)、鸢尾黄酮A(3)、5,7-二羟基-2′，6-二甲氧基异黄酮(4)、鸢尾素B(5)、5,3′-二羟基-7,8,2′-三甲氧基异黄酮(6)和鸢尾素A(7)。通过广泛的核磁共振和圆二色技术实现了1的结构解析。化合物1、5和7在HL-60细胞中表现出抗氧化活性（IC50值分别为21、11和3.8 μ g/mL），而化合物2、5和先前分离的鸢尾酮B在表达人雌激素受体（er - α）的酵母细胞中表现出雌激素反应（EC50值分别为305.5、159.7和322.0 μ g/mL）。
A new dihydroflavonol, songaricol (1) and seven known flavonoids, ayamenin A (2), irisflavone A (3), 5,7-dihydroxy-2',6-dimethoxyisoflavone (4), irilin B (5), 5,3'-dihydroxy-7,8,2'-trimethoxyisoflavone (6) and irisoid A (7) were isolated from rhizome and roots of Iris songarica. Structure elucidation of 1 was achieved through extensive NMR and circular dichroism techniques. Compounds 1, 5 and 7 showed antioxidant activity in HL-60 cells (IC50 values of 21, 11 and 3.8 mu g/mL), whereas 2, 5 and the previously isolated irisone B were able to show estrogenic response (EC50 values of 305.5, 159.7 and 322.0 mu g/mL) in yeast cells expressing human estrogen receptor (ER-alpha).