Schema cells in the macaque hippocampus
Schema cells in the macaque hippocampus
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DOI：
10.1126/science.aav5404
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发表时间：
2019-02-08
期刊：
影响因子：
56.9
通讯作者：
Wirth, S.
中科院分区：
文献类型：
--
作者：
Baraduc, P.;Duhamel, J. -R.;Wirth, S.
人类海马体中的概念细胞对刺激传达的意义进行编码，而不是对刺激的感知方面进行编码。本文研究猕猴的类似细胞是否能够形成空间环境的概念图式。每天，研究人员向猴子展示一个熟悉的和一个新的虚拟迷宫，它们共享一个共同的图式，但表面特征（地标）有所不同。在这两种环境中，动物都在寻找与地标相关的隐藏奖励目标。在学习过程中，许多神经元形成了一个放电图，整合了新迷宫中以目标为中心和任务相关的信息，与熟悉的迷宫相匹配。因此，这些海马体细胞从环境的表面细节中抽象出空间概念，并将空间编码为类似图式的表征。
Concept cells in the human hippocampus encode the meaning conveyed by stimuli over their perceptual aspects. Here we investigate whether analogous cells in the macaque can form conceptual schemas of spatial environments. Each day, monkeys were presented with a familiar and a novel virtual maze, sharing a common schema but differing by surface features (landmarks). In both environments, animals searched for a hidden reward goal only defined in relation to landmarks. With learning, many neurons developed a firing map integrating goal-centered and task-related information of the novelmaze thatmatched that for the familiar maze. Thus, these hippocampal cells abstract the spatial concepts from the superficial details of the environment and encode space into a schema-like representation.