THE BINDING-SITE ON ICAM-1 FOR PLASMODIUM-FALCIPARUM INFECTED ERYTHROCYTES OVERLAPS, BUT IS DISTINCT FROM, THE LFA-1-BINDING SITE
THE BINDING-SITE ON ICAM-1 FOR PLASMODIUM-FALCIPARUM INFECTED ERYTHROCYTES OVERLAPS, BUT IS DISTINCT FROM, THE LFA-1-BINDING SITE
复制标题
DOI：
10.1016/0092-8674(92)90207-s
复制
发表时间：
1992-01-10
期刊：
影响因子：
64.5
通讯作者：
HOGG, N
中科院分区：
文献类型：
--
作者：
BERENDT, AR;MCDOWALL, A;HOGG, N
细胞间粘附分子-1（ICAM-1，CD 54）是介导恶性疟原虫感染红细胞体外细胞粘附的三种假定内皮受体之一。由于细胞粘附到毛细血管后微静脉内皮被认为是恶性疟原虫疟疾的毒力的主要因素，我们已经检查了ICAM-1和恶性疟原虫感染的细胞之间的相互作用，并将其与生理性反受体，白细胞整合素LFA-1的相互作用进行了比较。我们的研究结果表明，疟疾结合位点位于ICAM-1分子的前两个结构域，与LFA-1位点重叠，但与LFA-1位点不同。
The intercellular adhesion molecule-1 (ICAM-1, CD54) is one of three putative endothelial receptors that mediate in vitro cytoadherence of P. falciparum-infected erythrocytes. Since cytoadherence to postcapillary venular endothelium is thought to be a major factor in the virulence of P. falciparum malaria, we have examined the interaction between ICAM-1 and the P. falciparum-infected cell, and have compared it with the interaction to the physiological counter receptor, the leukocyte integrin LFA-1. Our results demonstrate that the malaria-binding site resides in the first two domains of the ICAM-1 molecule and overlaps, but is distinct from, the LFA-1 site.