Single nucleotide polymorphisms of the Fas gene are associated with papillary thyroid cancer
Single nucleotide polymorphisms of the Fas gene are associated with papillary thyroid cancer
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DOI：
10.1016/j.anl.2015.02.001
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发表时间：
2015-08-01
影响因子：
1.7
通讯作者：
Park, Il Seok
中科院分区：
文献类型：
--
作者：
Eun, Young Gyu;Lee, Young Chan;Park, Il Seok
目的：Fas是肿瘤坏死因子（TNF）受体家族中死亡受体亚群的原型代表。最近，Fas或Fas配体（FasL）基因的单核苷酸多态性（SNP）已被证明与几种癌症的风险增加和几种癌症的预后相关。本研究的目的是评估Fas和FasL基因的SNPs与甲状腺乳头状癌（PTC）之间的关联，并评估这些SNPs和PTC的临床病理特征之间的关系。方法：5个SNPs位于两个基因的Fas和FasL基因在94例PTC患者和364名健康对照组采用直接测序法进行基因分型。使用市售软件分析遗传数据。结果：基因分型结果显示Fas基因内含子（rs 1571013）、启动子（r51800682）和3 '-UTR（rs 1468063）的SNP与PTC的发生密切相关。我们还检测到PTC患者和健康对照组之间Fas基因等位基因频率的显着差异。此外，我们发现Fas基因3 '-UTR SNP（rs 1468063）与PTC的多灶性相关[显性模型，OR 0.28，p = 0.028;对数加性模型，OR 0.43，p = 0.033]。此外，Fas SNP与PTC的多灶性之间存在显著相关性。(C)2015爱思唯尔爱尔兰有限公司版权所有。
Objectives: Fas is the prototypic representative of the death receptor subgroup of the tumor necrosis factor (TNF) receptor family. Recently, single nucleotide polymorphisms (SNPs) of the Fas or Fas ligand (FasL) genes have been shown to be associated with an increased risk of several cancers and with the prognosis of several cancers. The objective of this study was to evaluate the association between the SNPs of the Fas and FasL genes and papillary thyroid cancer (PTC) and to assess the relationship between these SNPs and the clinicopathological characteristics of PTC.Methods: Five SNPs located within the two genes of Fas and FasL were genotyped using direct sequencing in 94 patients with PTC and 364 healthy controls. Genetic data were analyzed using commercially available software. And, the statistical analyses were performed according to clinicopathologic characteristics of PTC.Results: Genotyping analysis demonstrated that the intron SNP (rs1571013), promoter SNP (r51800682) and 3'-UTR SNP (rs1468063) of Fas were significantly associated with the development of PTC. We also detected a significant difference between patients with PTC and healthy controls with respect to Fas gene allele frequencies. Furthermore, we found that the 3'-UTR SNP (rs1468063) of Fas was associated with the multifocality of cancer [dominant model, OR 0.28, p = 0.028; log-additive model, OR 0.43, p = 0.033].Conclusion: We observed a significant association between SNPs of the Fas gene and the development of PTC. In addition, there was a significant association between a Fas SNP and the multifocality of PTC. (C) 2015 Elsevier Ireland Ltd. All rights reserved.