Increased Dendritic Orientation Dispersion in the Left Occipital Gyrus is Associated with Atypical Visual Processing in Adults with Autism Spectrum Disorder.
Increased Dendritic Orientation Dispersion in the Left Occipital Gyrus is Associated with Atypical Visual Processing in Adults with Autism Spectrum Disorder.
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DOI：
10.1093/cercor/bhaa121
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发表时间：
2020-06
期刊：
影响因子：
3.7
通讯作者：
K. Matsuoka;M. Makinodan;S. Kitamura;Masato Takahashi;Hiroaki Yoshikawa;F. Yasuno;Rio Ishida;Naoko Kishimoto;Y. Yasuda;R. Hashimoto;T. Taoka;T. Miyasaka;K. Kichikawa;T. Kishimoto
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作者：
K. Matsuoka;M. Makinodan;S. Kitamura;Masato Takahashi;Hiroaki Yoshikawa;F. Yasuno;Rio Ishida;Naoko Kishimoto;Y. Yasuda;R. Hashimoto;T. Taoka;T. Miyasaka;K. Kichikawa;T. Kishimoto
在自闭症谱系障碍（ASD）中，复杂性特异性假说解释了非典型视觉加工可归因于视觉通路的选择性功能改变。我们研究了树突微观结构及其与功能连接（FC）的关系。参与者包括28名自闭症患者和29名正常发育者。我们探讨了神经突定向弥散和密度成像（NODDI）的变化，以及在感兴趣的探索区域中，FC与NODDI参数显著相关的脑区。ASD个体在与第二视觉皮层（V2）对应的左枕回（OG）中取向弥散指数（ODI）显著升高。左脑OG和左颞中回之间的FC值与平均ODI值呈显著负相关。左侧OG的平均ODI值与青少年/成人感觉剖面（AASP）视觉象限的低配准显著正相关，导致与AASP视觉象限的被动行为反应显著正相关；此外，左脑OG和左脑MTG之间的FC值与互惠社会互动呈显著负相关。我们的研究结果表明，通过改变腹侧视觉通路的中介，异常的V2树突树突化与非典型视觉加工有关。
In autism spectrum disorder (ASD), the complexity-specific hypothesis explains that atypical visual processing is attributable to selective functional changes in visual pathways. We investigated dendritic microstructures and their associations with functional connectivity (FC). Participants included 28 individuals with ASD and 29 typically developed persons. We explored changes in neurite orientation dispersion and density imaging (NODDI) and brain areas whose FC was significantly correlated with NODDI parameters in the explored regions of interests. Individuals with ASD showed significantly higher orientation dispersion index (ODI) values in the left occipital gyrus (OG) corresponding to the secondary visual cortex (V2). FC values between the left OG and the left middle temporal gyrus (MTG) were significantly negatively correlated with mean ODI values. The mean ODI values in the left OG were significantly positively associated with low registration of the visual quadrants of the Adolescent/Adult Sensory Profile (AASP), resulting in a significant positive correlation with passive behavioral responses of the AASP visual quadrants; additionally, the FC values between the left OG and the left MTG were significantly negatively associated with reciprocal social interaction. Our results suggest that abnormal V2 dendritic arborization is associated with atypical visual processing by altered intermediation in the ventral visual pathway.