EPILEPSY, DEMENTIA AND ADAPTIVE-BEHAVIOR IN DOWNS-SYNDROME
EPILEPSY, DEMENTIA AND ADAPTIVE-BEHAVIOR IN DOWNS-SYNDROME
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DOI：
10.1111/j.1365-2788.1993.tb00582.x
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发表时间：
1993-04-01
影响因子：
3.6
通讯作者：
COLLACOTT, RA
中科院分区：
文献类型：
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作者：
COLLACOTT, RA
广泛调查发现，英格兰莱斯特郡有 378 名患有唐氏综合症的成年人。 为了确定既往癫痫病史，包括癫痫发作开始的年龄，对其中 351 名患者 (92.8%) 的直接护理人员进行了访谈。还邀请直接护理人员提供信息，以便完成适应性行为量表 (A.B.S.) 评级。根据癫痫发作是否发生在 35 岁之前或之后，有癫痫病史的个体被分为两组。选择了两个对照组，其中有唐氏综合症患者，但没有癫痫病史。那些在较年轻时开始癫痫发作的患者的适应性行为量表评分与那些没有癫痫发作史记录的患者相似。然而，对于那些晚年开始癫痫发作的人来说，A.B.S. 所有领域的得分都很高。与年轻癫痫患者及其对照者相比，这些症状显着减少。老年对照组的适应性行为量表评分处于中间位置，表明迟发性癫痫可能是痴呆过程的晚期表现。病例记录中记录的痴呆症临床诊断与晚发性癫痫的存在显着相关。 这支持了唐氏综合症患者迟发性癫痫与阿尔茨海默病相关的假设。
Widespread enquiry identified 378 adults with Down's syndrome resident in Leicestershire, England. The immediate carer of 351 of these (92.8%) was interviewed for the purpose of establishing a past history of seizures, including the age at which the seizures,began. The immediate carer was also invited to provide information to enable the completion of an Adaptive Behaviour Scale (A.B.S.) rating. Individuals with a history of seizures were divided into two groups on the basis of whether or not seizures commenced prior to or after age 35 years. Two control groups of individuals with Down's syndrome, but without a history of seizures were selected. Adaptive Behaviour Scale scores for those in whom seizures commenced at a younger age were similar to those who had no recorded history of seizures. However, in those in whom seizures began in later life, scores on all domains of the A.B.S. were significantly reduced compared to both young epileptic patients and their controls. Adaptive Behaviour Scale scores for the older control group held an intermediate position, suggesting that late-onset epilepsy may be a late manifestation of a dementing process. A clinical diagnosis of dementia recorded in the case records was significantly associated with the presence of late-onset epilepsy. This is supportive of the hypothesis that late-onset epilepsy in individuals with Down's syndrome is associated with Alzheimer's disease.