Relationship Between White Matter Microstructure and Hallucination Severity in the Early Stages of Psychosis: A Diffusion Tensor Imaging Study
Relationship Between White Matter Microstructure and Hallucination Severity in the Early Stages of Psychosis: A Diffusion Tensor Imaging Study
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DOI：
10.1093/schizbullopen/sgab015
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发表时间：
2021-05
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影响因子：
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通讯作者：
Yutaro Sato;A. Sakuma;N. Ohmuro;M. Katsura;Koichi Abe;Kazuho Tomimoto;Kunio Iizuka;F. Ito
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文献类型：
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作者：
Yutaro Sato;A. Sakuma;N. Ohmuro;M. Katsura;Koichi Abe;Kazuho Tomimoto;Kunio Iizuka;F. Ito
扩散张量成像（DTI）研究了精神分裂症幻觉与白色物质（WM）微观结构之间的关系。然而，只有少数研究集中在精神病早期阶段的幻觉严重程度，并且WM微观结构在幻觉发展中的参与仍然不清楚。本研究旨在探讨精神病早期阶段与幻觉严重程度相关的工作记忆微观结构。使用基于轨迹的空间统计（TBSS）的DTI分析应用于138名参与者，包括105名患有早期精神病的个体（56名患有精神病临床高风险的个体[100]和49名患有首次发作精神病的个体[FEP]）和33名健康对照（HC）。对各向异性分数（FA）、平均扩散率（MD）、径向扩散率（RD）和轴向扩散率（AD）进行组间比较。我们研究了FA，MD，RD和AD与精神病早期幻觉严重程度的关系。与HC相比，在精神病的早期阶段，观察到多个WM道的FA较低，MD和RD较高。我们发现幻觉严重程度与WM束MD增加之间存在关联，WM束主要由左侧上级纵束（SLF）和额枕下束（IFOF）组成。我们的研究结果表明，与语言处理相关的大脑网络的连接障碍与幻觉的发展有关。需要对精神病的早期阶段进行进一步的研究，以阐明幻觉的机制。
Diffusion tensor imaging (DTI) studies have investigated the relationship between hallucinations in schizophrenia and white matter (WM) microstructure. However, only a few studies have focused on hallucination severity in the early stages of psychosis, and the involvement of the WM microstructure in the development of hallucinations remains unclear. This study aimed to examine the WM microstructure related to hallucination severity in the early stages of psychosis. DTI analysis using tract-based spatial statistics (TBSS) was applied to 138 participants, consisting of 105 individuals with early stages of psychosis (56 individuals with clinical high risk for psychosis [CHR] and 49 individuals with first-episode psychosis [FEP]) and 33 healthy controls (HCs). Group comparisons of fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) were performed. We examined the association of FA, MD, RD, and AD with hallucination severity in the early stages of psychosis. Lower FA and higher MD and RD in multiple WM tracts were observed in the early stages of psychosis compared to HCs. We found an association between hallucination severity and increased MD in the WM tract, consisting mainly of the left superior longitudinal fasciculus (SLF) and inferior fronto-occipital fasciculus (IFOF). Our findings indicate that dysconnectivity in brain networks associated with language processing is related to the development of hallucinations. Further studies of the early stages of psychosis are needed to elucidate the mechanism of hallucinations.