Increased prostatic lysophosphatidylcholine acyltransferase activity in human prostate cancer: A marker for malignancy
Increased prostatic lysophosphatidylcholine acyltransferase activity in human prostate cancer: A marker for malignancy
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DOI：
10.1097/00005392-200102000-00026
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发表时间：
2001-02-01
影响因子：
6.6
通讯作者：
Johnson, D
中科院分区：
文献类型：
--
作者：
Faas, FH;Dang, AQ;Johnson, D
目的：磷脂酶A2和溶血磷脂酰胆碱酰基转移酶（LAT）构成一个脱酰-再酰化循环，将花生四烯酸掺入脂质膜。在一份初步报告中，我们发现恶性前列腺组织中LAT活性增加。我们测量了大量接受前列腺切除术的患者的前列腺组织中的LAT活性。来自93名接受前列腺癌根治性前列腺切除术的患者的前列腺组织，14名接受膀胱癌膀胱切除术的患者的前列腺组织，分析了55例因良性前列腺增生症接受经尿道电切术和11例因前列腺癌接受经尿道电切术以缓解梗阻症状的LAT结果：在使用油酰辅酶A作为底物的根治性直肠癌切除术标本中，同一标本的恶性和良性部分之间LAT活性的平均增加为0.68 ± 0.12 nmol/L。mg.蛋白质/分钟（p
Purpose: Phospholipase A2 and lysophosphatidylcholine acyltransferase (LAT) constitute a deacylation-reacylation cycle that incorporates arachidonic acid into the lipid membrane. In a preliminary report we found increased LAT activity in malignant prostate tissue. We measured LAT activity in prostate tissue from a large number of patients undergoing prostatectomy.Materials and Methods: Prostate tissue from 93 patients undergoing radical prostatectomy for prostate carcinoma, 14 undergoing cystoprostatectomy for bladder cancer, 55 undergoing transurethral resection for benign prostatic hyperplasia and 11 with prostate cancer undergoing transurethral resection for relief of obstructive symptoms was analyzed for LAT activity.Results: In radical prostatectomy specimens using oleoyl coenzyme A as substrate mean increase in LAT activity between malignant and benign portions of the same specimen was 0.68 +/- 0.12 nmol./mg. protein per minute (p