RELATIONSHIPS BETWEEN SPLEEN PLATELETS AND FACTOR 8 LEVELS
RELATIONSHIPS BETWEEN SPLEEN PLATELETS AND FACTOR 8 LEVELS
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DOI：
10.1182/blood.v31.3.358.358
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发表时间：
1968-01-01
期刊：
影响因子：
20.3
通讯作者：
SHULMAN, NR
中科院分区：
文献类型：
--
作者：
LIBRE, EP;COWAN, DH;SHULMAN, NR
脾对于肾上腺素[肾上腺素]输注和其他急性应激刺激后观察到的因子VIII升高至关重要。脾似乎能够储存和释放因子VIII，或从其他部位释放因子VIII。凝血因子VIII升高似乎不依赖于肾上腺素治疗后伴随的血小板升高。在与慢性血小板减少症或血小板增多症相关的病理状态中经常发现血小板和因子VIII水平之间的反比关系。血小板输注似乎不影响因子VIII水平。在体外尝试证明在存在和不存在肾上腺素的情况下血小板吸附因子VIII或从血小板洗脱因子VIII均未成功。
The spleen is essential for the Factor VIII elevations observed after adrenalin [epiriephrine] infusion and other acutely stressful stimuli. The spleen appears to be capable of either storing and releasing Factor VIII, or of effecting release of Factor VIII from some other site. The Factor VIII elevations do not appear to be dependent on the concomitant platelet rises that occur after epinephrine. An inverse relationship between platelet and Factor VIII levels is frequently found in pathological states associated with chronic thrombocytopenia or thrombocytosis. Platelet transfusions do not appear to influence Factor VIII levels. In vitro attempts to demonstrate adsorption of Factor VIII by platelets or elution of Factor VIII from platelets in the presence and absence of epinephrine were not successful.