Detection of prostate cancer with 11C-methionine positron emission tomography
Detection of prostate cancer with 11C-methionine positron emission tomography
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DOI：
10.1097/01.ju.0000148326.71981.44
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发表时间：
2005-01-01
影响因子：
6.6
通讯作者：
Tóth, C
中科院分区：
文献类型：
--
作者：
Tóth, G;Lengyel, Z;Tóth, C
目的：我们研究了检测原发性前列腺癌与正电子发射断层扫描（PET）使用C-11-标记的蛋氨酸（MET）在患者的前列腺特异性抗原（PSA）水平升高和重复阴性pipes.Materials和方法：共20例连续患者血清PSA升高和阴性重复活检被列入研究。患者年龄范围为52 - 75岁（平均65岁）。PSA水平范围为3.49至28.6 ng/ml（平均9.36）。使用C-11标记的MET从前列腺区域获得动态PET图像。可疑的示踪剂的积累解剖定位使用磁共振图像，并作为指导下一次biopsiz.Results：PET阳性15例（75%），其中7人（46.7%），下一次重复活检证实癌。在整个组和阳性PET组中，总体检出率分别为35%（7/20）和46.7%（7/15）。5例MET PET阴性患者中5例活检均阴性。结论：对PSA升高、多次活检阴性的患者行MET PET短时间动态扫描及多中心穿刺活检，可提高前列腺癌的检出率。
Purpose: We studied the detection of primary prostate cancer with positron emission tomography (PET) using C-11-labeled methionine (MET) in patients with increased prostate specific antigen (PSA) levels and repeatedly negative biopsies.Materials and Methods: A total of 20 consecutive patients with increased serum PSA and negative repeat biopsies were included in the study. Patient age ranged from 52 to 75 years (average 65). PSA levels ranged from 3.49 to 28.6 ng/ml (average 9.36). Dynamic PET images were obtained from the prostate region using C-11-labeled MET. Suspicious accumulations of the tracer were anatomically localized using magnetic resonance images and were used as guidance during the next biopsy.Results: PET was positive in 15 (75%) patients, in 7 of whom (46.7%) the next repeat biopsy verified carcinoma. The overall detection rate was 35% (7 of 20) and 46.7% (7 of 15) in the whole group and in the positive PET group, respectively. All 5 of 5 patients with negative MET PET had negative biopsies.Conclusions: MET PET of the prostate with short dynamic scanning and multicore biopsy is a useful method to ensure a high detection rate of prostate cancer in patients with increased PSA and repeat negative biopsies.