Mechanisms regulating the origins of the vertebrate vascular system.
Mechanisms regulating the origins of the vertebrate vascular system.
复制标题
调节脊椎动物血管系统起源的机制。
DOI：
10.1002/jcb.20196
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Sipe,ConorW
中科院分区：
文献类型：
--
作者：
Saha,MargaretS;Cox,ElizabethA;Sipe,ConorW
为了维持生长、分化和器官发生，脊椎动物胚胎必须在胚胎发育早期形成功能性的血管系统。对这一过程的内在兴趣以及潜在的临床应用前景已经导致了对血管系统形成机制的理解取得了重大进展，但是血管发育的最早阶段--中胚层中定向内皮前体的出现--仍然不清楚。目前的文献综述揭示了一个意想不到的多样性和异质性方面的血管内皮细胞起源于胚胎，当他们成为承诺和机制如何内皮细胞获得他们的身份。在空间上，早期中胚层的广泛区域具有产生血管内皮细胞的能力;在时间上，该过程不限于胚胎发生期间的小窗口，而是可以在生物体的整个寿命中持续。在分子水平上，最近的研究结果指出，几个决定性的途径，调节，调制和扩展的范围Flk 1/VEGF信号系统。内皮细胞类型决定中涉及的一系列新的基因产物似乎协同作用，不同的因素组合导致不同的细胞反应，不同的分化模式，以及胚胎发生过程中内皮细胞类型的相当大的异质性。© 2004 Wiley利斯公司
In order to sustain growth, differentiation, and organogenesis, vertebrate embryos must form a functional vascular system early in embryonic development. Intrinsic interest in this process as well as the promise of potential clinical applications has led to significant progress in understanding the mechanisms governing the formation of the vascular system, however the earliest stages of vascular development—the emergence of committed endothelial precursors from the mesoderm—remain unclear. A review of the current literature reveals an unexpected diversity and heterogeneity with respect to where vascular endothelial cells originate in the embryo, when they become committed and the mechanisms governing how endothelial cells acquire their identity. Spatially, a widespread region of the early mesoderm possesses the ability to give rise to vascular endothelial cells; temporally the process is not limited to a small window during embryogenesis, but rather, may continue throughout the lifespan of the organism. On the molecular level, recent findings point to several determinative pathways that regulate, modulate, and extend the scope of the Flk1/VEGF signaling system. An expanding array of novel gene products implicated in endothelial cell type determination appear to act synergistically, with different combinations of factors leading to diverse cellular responses, varying patterns of differentiation, and considerable heterogeneity of endothelial cell types during embryogenesis. © 2004 Wiley‐Liss, Inc.