Cross-species transmission of CWD prions
Cross-species transmission of CWD prions
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DOI：
10.1080/19336896.2015.1118603
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发表时间：
2016-01-02
期刊：
影响因子：
2.3
通讯作者：
Sigurdson, Christina J.
中科院分区：
文献类型：
--
作者：
Kurt, Timothy D.;Sigurdson, Christina J.
朊病毒在人类和动物中引起致命的神经退行性疾病，并可通过动物源性传播。慢性消耗性疾病（CWD）是一种高传染性的朊病毒疾病，影响野生鹿和麋鹿的鹿科动物在美国和加拿大的广泛地区。跨物种慢性消耗病传播的风险已经在一系列哺乳动物中进行了实验评估，包括非人类灵长类动物和表达人类细胞朊病毒蛋白的小鼠模型。在这里，我们审查跨物种CWD传输的决定因素，并提出一个模型，可以解释CWD传输到人类的结构障碍。
Prions cause fatal neurodegenerative diseases in humans and animals and can be transmitted zoonotically. Chronic wasting disease (CWD) is a highly transmissible prion disease of wild deer and elk that affects cervids over extensive regions of the United States and Canada. The risk of cross-species CWD transmission has been experimentally evaluated in a wide array of mammals, including non-human primates and mouse models expressing human cellular prion protein. Here we review the determinants of cross-species CWD transmission, and propose a model that may explain a structural barrier for CWD transmission to humans.