Clinical factors that impair health-related quality of life in ulcerative colitis patients vary with the disease duration
Clinical factors that impair health-related quality of life in ulcerative colitis patients vary with the disease duration
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DOI：
10.1097/meg.0b013e3282f5e9c9
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发表时间：
2008-07-01
影响因子：
2.1
通讯作者：
Shiratori, Yasushi
中科院分区：
文献类型：
--
作者：
Kuriyama, Motoaki;Katoa, Jun;Shiratori, Yasushi
背景与目的溃疡性结肠炎（UC）患者的健康相关生活质量（HRQOL）可能因慢性症状而受损。虽然UC患者长期存在这些症状，但关于HRQOL随病程变化的报道很少。这项研究的目的是澄清这些变化。方法采用经验证的日本版炎症性肠病问卷（J-IBDQ）对331例日本UC患者的HRQOL进行调查。采用多元线性回归分析确定HRQOL及影响HRQOL的因素，按病程分层。结果在15个临床因素中，临床活动指数评分是最重要的决定因素(P
Background and aim The health-related quality of life (HRQOL) of patients with ulcerative colitis (UC) can be impaired because of the chronic symptoms. Although UC patients suffer from such symptoms over the long term, there have been few reports on the changes of HRQOL with disease duration. The aim of this study was to clarify these changes.Methods The HRQOL of 331 Japanese UC patients was examined using the validated Japanese version of the Inflammatory Bowel Disease Questionnaire (J-IBDQ). HRQOL and factors affecting HRQOL identified using multiple linear regression analysis were stratified by disease duration.Results Of the 15 clinical factors examined, the clinical activity index score was the strongest determinant (P