Subunit vaccines for the prevention of mucosal infection with Chlamydia trachomatis.
Subunit vaccines for the prevention of mucosal infection with Chlamydia trachomatis.
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DOI：
10.1586/14760584.2016.1161510
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发表时间：
2016-08
影响因子：
6.2
通讯作者：
Brunham RC
中科院分区：
文献类型：
--
作者：
Yu H;Karunakaran KP;Jiang X;Brunham RC
沙眼衣原体是女性输卵管性不孕症最常见的可预防原因。在高收入国家，尽管采取了公共卫生控制措施，C。沙眼发病率继续上升。大多数中等和低收入国家缺乏任何衣原体控制计划;因此，疫苗对于控制衣原体感染至关重要。合理设计的衣原体疫苗需要了解保护性免疫的免疫学相关性、对这种粘膜病原体的病理反应、鉴定最佳疫苗抗原和选择产生保护性免疫的合适佐剂递送系统。幸运的是，衣原体疫苗学是由基因组知识和复制人类衣原体的许多特征的小鼠模型促进的。沙眼感染本文综述了近年来在这些领域的进展，重点是亚单位疫苗的发展。
Chlamydia trachomatis is the most common preventable cause of tubal infertility in women. In high-income countries, despite public health control efforts, C. trachomatis case rates continue to rise. Most medium and low-income countries lack any Chlamydia control program; therefore, a vaccine is essential for the control of Chlamydia infections. A rationally designed Chlamydia vaccine requires understanding of the immunological correlates of protective immunity, pathological responses to this mucosal pathogen, identification of optimal vaccine antigens and selection of suitable adjuvant delivery systems that engender protective immunity. Fortunately, Chlamydia vaccinology is facilitated by genomic knowledge and by murine models that reproduce many of the features of human C. trachomatis infection. This article reviews recent progress in these areas with a focus on subunit vaccine development.