Acid tolerance mechanisms utilized by Streptococcus mutans.

Acid tolerance mechanisms utilized by Streptococcus mutans.
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DOI:
10.2217/fmb.09.129
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发表时间:
2010-03
影响因子:
3.1
通讯作者:
Cvitkovitch D
Cvitkovitch D
中科院分区:
生物学3区
文献类型:
--
作者:
Matsui R;Cvitkovitch D

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自1924年由J Clarke发现以来,变形链球菌一直是严格研究工作的重点,因为它参与龋齿的发生和发展。它发酵一系列膳食碳水化合物的能力可以迅速降低外部环境的pH值,从而使牙菌斑不适合许多竞争物种,并最终导致蛀牙。这种口腔病原体产生的酸如果不是利用各种高度进化的耐酸机制来抵抗酸冲击的非凡能力,就会被证明是自杀性的。这些机制的阐明将被讨论,作为本次审查的重点。
Since its discovery in 1924 by J Clarke, Streptococcus mutans has been the focus of rigorous research efforts due to its involvement in caries initiation and progression. Its ability to ferment a range of dietary carbohydrates can rapidly drop the external environmental pH, thereby making dental plaque inhabitable to many competing species and can ultimately lead to tooth decay. Acid production by this oral pathogen would prove suicidal if not for its remarkable ability to withstand the acid onslaught by utilizing a wide variety of highly evolved acid-tolerance mechanisms. The elucidation of these mechanisms will be discussed, serving as the focus of this review.
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