Sleep disturbances and depression: a challenge for antidepressants
Sleep disturbances and depression: a challenge for antidepressants
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DOI：
10.1097/01.yic.0000195658.91524.61
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发表时间：
2006-02-01
影响因子：
2.6
通讯作者：
Lam, RW
中科院分区：
文献类型：
--
作者：
Lam, RW
睡眠障碍是抑郁症患者的常见症状，睡眠结构异常是重度抑郁症最强有力的心理生物学相关因素之一。大多数抗抑郁药改变睡眠的生理模式，并最终改善睡眠症状，沿着其他抑郁症状。然而，许多抗抑郁药也对睡眠有不良影响，特别是引起或加重失眠，白天嗜睡或镇静。本文简要回顾了睡眠的生物学，与抑郁症相关的睡眠障碍，以及抗抑郁药对睡眠的治疗和不良影响。它还描述了一种新的抗抑郁药阿戈美拉汀，它可以改善抑郁症的症状，并迅速缓解睡眠投诉，而没有镇静作用。
Sleep disturbances are commonly experienced by depressed patients, and abnormalities of sleep architecture are among the most robust psychobiological correlates of major depression. Most antidepressants alter the physiological patterns of sleep and eventually improve sleep symptoms, along with other symptoms of depression. However, many antidepressants also have unwanted adverse effects on sleep, notably by causing or worsening insomnia, daytime sleepiness or sedation. This article briefly reviews the biology of sleep, the sleep disturbances associated with depression, and the therapeutic and adverse effects of antidepressants on sleep. It also describes a novel antidepressant, agomelatine, which improves symptoms of depression and rapidly relieves sleep complaints without sedative effects.