ERP changes in alcoholics with and without alcohol psychosis
ERP changes in alcoholics with and without alcohol psychosis
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DOI：
10.1016/0006-3223(95)00289-8
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发表时间：
1996-05-15
影响因子：
10.6
通讯作者：
Engel, RR
中科院分区：
文献类型：
--
作者：
Kathmann, N;Soyka, M;Engel, RR
本研究比较了不同并发症的慢性酒精依赖者在酒精戒断过程中事件相关脑电位（ERPs）的变化。20个只有轻度至中度酒精戒断症状的酗酒者，两组酗酒者的历史，无论是谵妄性谵妄（n = 9）或酒精幻觉症（n = 13），和对照组的38个非酗酒者进行了检查。患者在未服药状态下进行测试，且不早于戒酒后14天。听觉Oddball范式和视觉字母匹配范式被用作认知任务。点燃听觉任务时，与非酒精组相比，所有酒精组的N200和P300潜伏期延迟，P300波幅降低。在视觉任务中，只有P300振幅显著降低。患有谵妄或酒精幻觉症的患者比没有并发症的戒断综合征的酗酒者表现出更大的Oddball P300振幅。此外，谵妄和幻觉症患者的ERP不同，幻觉症患者在听觉Oddball和字母匹配任务中均显示出较早的P300峰值。它的结论是，在戒酒过程中ERPs的变化可能反映了特定的神经生理功能障碍，酗酒者倾向于不同的酒精相关精神病。
The present study compared alterations of event-related brain potentials (ERPs) in subgroups of chronic alcoholics with different complications during alcohol withdrawal. Twenty alcoholics with only mild to moderate alcohol withdrawal symptoms, two groups of alcoholics with histories of either delirium tremens (n = 9) or alcohol hallucinosis (n = 13), and a control group of 38 nonalcoholics were examined. Patients were tested in unmedicated state and not earlier than 14 days after drinking cessation. An auditory Oddball paradigm and a visual Letter Matching paradigm were used as cognitive tasks. lit the auditory task, all alcoholic groups exhibited delayed N200 and P300 latencies and a reduced P300 amplitude as compared to nonalcoholics. In the visual task, only P300 amplitude was significantly diminished. Patients having suffered from delirium tremens or alcohol hallucinosis showed greater Oddball P300 amplitudes than alcoholics with uncomplicated withdrawal syndrome. Furthermore, delirium and hallucinosis patients differed in their ERPs, with hallucinosis patients showing an earlier P300 peak in both the auditory Oddball and the Letter Matching task. It is concluded that changes in ERPs during abstinence might reflect specific neurophysiological dysfunctions in alcoholics prone to different alcohol-related psychoses.