The ipsilaterally evoked olivocochlear reflex causes rapid adaptation of the 2f(1)-f(2) distortion product otoacoustic emission
The ipsilaterally evoked olivocochlear reflex causes rapid adaptation of the 2f(1)-f(2) distortion product otoacoustic emission
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DOI：
10.1121/1.414956
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发表时间：
1996-06-01
影响因子：
2.4
通讯作者：
Guinan, JJ
中科院分区：
文献类型：
--
作者：
Liberman, MC;Puria, S;Guinan, JJ
以小于 70 ms 的时间分辨率测量麻醉猫在 2f(1)-f(2) 时畸变产物耳声发射 (DPOAE) 的起始行为。在主音调出现后，DPOAE 的幅度会在单耳刺激时调整多达 6 dB，在双耳呈现主音调时调整 10 dB。 DPOAE 自适应由一个大型、快速的组件（时间常数约为 100 ms）和一个小型、较慢的组件（时间常数约为 1000 ms）组成。当仅切断交叉橄榄耳蜗束 (OCB) 时，快速适应就会消失，而在 OCB 完全切断后，缓慢适应仍然存在。 OC 部分快速适应的丧失伴随着 DPOAE 稳态振幅的随之增加，因此完整的 OC 反射可以显着改变常规测量期间获得的 DPOAE。单耳诱发的 2f(1)-f(2) DPOAE 的快速适应可能是由支配外毛细胞的同侧反应性 OC 神经元的反射活动介导的。这种同侧反射油 DPOAE 幅度的影响通常是对侧反射的两倍，大概是因为同侧反应性 OC 神经元的数量是对侧反射油的两倍。基于快速适应现象的同侧 OC 反射测试对于人类受试者来说应该是可行且有用的。 (C) 1996 年美国声学学会。
The onset behavior of the distortion product otoacoustic emission (DPOAE) at 2f(1)-f(2) in anesthetized cats was measured with temporal resolution finer than 70 ms. The amplitude of the DPOAE adapts after onset of the primary tones by as much as 6 dB for monaural stimulation and 10 dB when the primaries are presented binaurally. DPOAE adaptation consists oa large, rapid component, with a time constant of roughly 100 ms, and a small, slower component with a time constant of roughly 1000 ms. The rapid component disappears when only the crossed olivocochlear bundle (OCB) is cut, whereas the slow adaptation persists after complete OCB section. The loss of rapid adaptation upon OC section is accompanied by a concomitant increase in the steady-slate amplitude of the DPOAE, Thus an intact OC reflex can significantly alter DPOAEs obtained during routine measurement. Rapid adaptation of the monaurally evoked 2f(1)-f(2) DPOAE is probably mediated by reflex activity in ipsilaterally responsive OC neurons innervating outer hair cells. The effects of this ipsilateral reflex oil DPOAE amplitudes are typically twice as large as those of the contralateral reflex, presumably because there are twice as many ipsilaterally responsive OC neurons. Tests for the ipsilateral OC reflex based on the phenomenon of rapid adaptation should be both feasible and useful in human subjects. (C) 1996 Acoustical Society of America.