Seroepidemiology of Campylobacter pylori infection in various populations
Seroepidemiology of Campylobacter pylori infection in various populations
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不同人群幽门弯曲菌感染的血清流行病学
DOI：
10.1128/jcm.27.8.1870-1873.1989
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发表时间：
1989
影响因子：
9.4
通讯作者：
D. Q. Hoa
中科院分区：
文献类型：
--
作者：
F. Mégraud;M.;F. Denis;A. Belbouri;D. Q. Hoa
幽门弯曲杆菌感染与慢性胃炎和十二指肠溃疡密切相关，但在正常人群中幽门螺杆菌感染的流行情况尚不清楚。采用酶联免疫吸附试验(EL ISA)，以两种菌株的声波提取液为抗原，对4个地理和社会经济地位不同的国家进行了血清学调查，尽可能随机选择具有代表性的人群。以600个酶联免疫吸附试验单位为临界值，其特异性为94%。在法国，很少有儿童在10岁之前感染。在60岁时，患病率逐渐上升到36.7%。这种随年龄增长的感染率在阿尔及利亚、越南和象牙海岸也观察到，但感染率较高(80%至90%)。在越南，和法国一样，很少有儿童感染幽门螺杆菌，而在非洲，幽门螺杆菌感染发生得更早。感染的患病率在特定年龄组中没有性别差异；在研究这些潜在危险因素时，在胃部症状、吸烟和饮酒习惯或城市或农村居住地方面也没有差异。与发达国家相比，发展中国家现有的消化性溃疡疾病的流行病学数据导致人们猜测，幽门螺杆菌感染不是发展这种疾病的充分条件。
Campylobacter pylori infection has been recognized as being strongly associated with chronic gastritis and duodenal ulceration, but the prevalence of C. pylori infection in a normal population is not known. A serological survey was conducted in four countries with different geographical and socioeconomic status, in a randomly chosen population as representative as possible, by using an enzyme-linked immunosorbent assay (ELISA) with a sonic extract of two strains as the antigen. The test had a specificity of 94% when 600 ELISA units was used as the threshold. In France, few children were infected before the age of 10 years. The prevalence then increased gradually to 36.7% in the sixth decade of life. This increasing prevalence of infection with age was also observed in Algeria, Vietnam, and the Ivory Coast but at a higher rate (80 to 90%). In Vietnam, as in France, few children were infected, whereas in Africa, C. pylori infection occurred earlier. The prevalence of infection did not differ with sex for a particular age group; it also did not differ with respect to gastric symptoms, smoking and drinking habits, or urban or rural residence when these potential risk factors were studied. The epidemiological data available on peptic ulcer disease in developing countries compared with developed countries led to the speculation that infection with C. pylori is not a sufficient condition to develop this disease.
幽门弯曲杆菌感染的流行病学：种族考虑。
DOI：
--
发表时间：
1988
期刊：
Scandinavian journal of gastroenterology. Supplement
影响因子：
--
作者：
Graham,DY;Klein,PD;Opekun,AR;Boutton,TW;EvansJr,DJ;Evans,DG;Alpert,LC;Michaletz,PA;Yoshimura,HH;Adam,E
通讯作者：
Adam,E