Practical Synthesis of α-Amyrin, β-Amyrin, and Lupeol: The Potential Natural Inhibitors of Human Oxidosqualene Cyclase
Practical Synthesis of α-Amyrin, β-Amyrin, and Lupeol: The Potential Natural Inhibitors of Human Oxidosqualene Cyclase
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α-香树脂醇、β-香树脂醇和羽扇豆醇的实际合成：人氧化角鲨烯环化酶的潜在天然抑制剂
DOI：
10.1002/ardp.201700178
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发表时间：
2017-12-01
影响因子：
5.1
通讯作者：
Liu, Jun
中科院分区：
文献类型：
--
作者：
Chen, Dongyin;Xu, Fengguo;Liu, Jun
A practical synthesis of alpha-amyrin (1), beta-amyrin (2), and lupeol (3) was accomplished in total yields of 32, 42, and 40% starting from easily available ursolic acid (4), oleanolic acid (5), and betulin (6), respectively. Remarkably, these three natural pentacyclic triterpenes exhibited potential inhibitory activity against human oxidosqualene cyclase.
